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    NRG1 neuregulin 1 [ Nomascus leucogenys (northern white-cheeked gibbon) ]

    Gene ID: 100587299, updated on 21-Jul-2018

    Summary

    Gene symbol
    NRG1
    Gene description
    neuregulin 1
    See related
    Ensembl:ENSNLEG00000012030
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Nomascus leucogenys
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae; Nomascus
    Orthologs

    Genomic context

    See NRG1 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    102 current Nleu_3.0 (GCF_000146795.2) 8 NC_019823.1 (37265384..38415555)

    Chromosome 8 - NC_019823.1Genomic Context describing neighboring genes Neighboring gene BTB/POZ domain-containing protein KCTD9 pseudogene Neighboring gene WRN RecQ like helicase Neighboring gene uncharacterized LOC105740172 Neighboring gene uncharacterized LOC105740142 Neighboring gene RNA-binding protein 4-like Neighboring gene fucosyltransferase 10

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_019823.1 Chromosome 8 Reference Nleu_3.0

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • EGFR tyrosine kinase inhibitor resistance, organism-specific biosystem (from KEGG)
      EGFR tyrosine kinase inhibitor resistance, organism-specific biosystemEGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which ...
    • EGFR tyrosine kinase inhibitor resistance, conserved biosystem (from KEGG)
      EGFR tyrosine kinase inhibitor resistance, conserved biosystemEGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which ...
    • ErbB signaling pathway, organism-specific biosystem (from KEGG)
      ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • ErbB signaling pathway, conserved biosystem (from KEGG)
      ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    pro-neuregulin-1, membrane-bound isoform

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Nomascus leucogenys Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Nleu_3.0

    Genomic

    1. NC_019823.1 Reference Nleu_3.0

      Range
      37265384..38415555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012508559.1XP_012364013.1  pro-neuregulin-1, membrane-bound isoform isoform X7

      Related
      ENSNLEP00000044399.1, ENSNLET00000047193.1
      Conserved Domains (4) summary
      cd05895
      Location:32106
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      smart00410
      Location:22108
      IG_like; Immunoglobulin like
      pfam00008
      Location:135165
      EGF; EGF-like domain
      pfam02158
      Location:185578
      Neuregulin; Neuregulin family
    2. XM_012508557.1XP_012364011.1  pro-neuregulin-1, membrane-bound isoform isoform X5

      Conserved Domains (4) summary
      cd05895
      Location:32106
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      smart00410
      Location:22108
      IG_like; Immunoglobulin like
      pfam00008
      Location:169199
      EGF; EGF-like domain
      pfam02158
      Location:219612
      Neuregulin; Neuregulin family
    3. XM_012508558.1XP_012364012.1  pro-neuregulin-1, membrane-bound isoform isoform X6

      Conserved Domains (4) summary
      cd05895
      Location:32106
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      smart00410
      Location:22108
      IG_like; Immunoglobulin like
      pfam00008
      Location:152182
      EGF; EGF-like domain
      pfam02158
      Location:202595
      Neuregulin; Neuregulin family
    4. XM_012508556.1XP_012364010.1  pro-neuregulin-1, membrane-bound isoform isoform X1

      Related
      ENSNLEP00000045791.1, ENSNLET00000045251.1
      Conserved Domains (4) summary
      cd05895
      Location:268342
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      smart00410
      Location:258344
      IG_like; Immunoglobulin like
      pfam00008
      Location:405435
      EGF; EGF-like domain
      pfam02158
      Location:455848
      Neuregulin; Neuregulin family
    5. XM_003269552.2XP_003269600.1  pro-neuregulin-1, membrane-bound isoform isoform X3

      Related
      ENSNLEP00000046568.1, ENSNLET00000039159.1
      Conserved Domains (4) summary
      cd05895
      Location:53127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      smart00410
      Location:43129
      IG_like; Immunoglobulin like
      pfam00008
      Location:190220
      EGF; EGF-like domain
      pfam02158
      Location:235628
      Neuregulin; Neuregulin family
    6. XM_003269550.2XP_003269598.1  pro-neuregulin-1, membrane-bound isoform isoform X2

      Related
      ENSNLEP00000036211.1, ENSNLET00000043871.1
      Conserved Domains (4) summary
      cd05895
      Location:53127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      smart00410
      Location:43129
      IG_like; Immunoglobulin like
      pfam00008
      Location:190220
      EGF; EGF-like domain
      pfam02158
      Location:240633
      Neuregulin; Neuregulin family
    7. XM_003269551.2XP_003269599.1  pro-neuregulin-1, membrane-bound isoform isoform X4

      Related
      ENSNLEP00000033394.1, ENSNLET00000054113.1
      Conserved Domains (4) summary
      cd05895
      Location:53127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      PHA03099
      Location:182271
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
      smart00410
      Location:43129
      IG_like; Immunoglobulin like
      pfam02158
      Location:232625
      Neuregulin; Neuregulin family
    8. XM_003269557.2XP_003269605.1  pro-neuregulin-1, membrane-bound isoform isoform X8

      Related
      ENSNLEP00000041394.1, ENSNLET00000033754.1
      Conserved Domains (4) summary
      cd05895
      Location:53127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      smart00410
      Location:43129
      IG_like; Immunoglobulin like
      pfam00008
      Location:190220
      EGF; EGF-like domain
      pfam02158
      Location:235424
      Neuregulin; Neuregulin family
    9. XM_003269554.2XP_003269602.1  pro-neuregulin-1, membrane-bound isoform isoform X9

      Conserved Domains (4) summary
      cd05895
      Location:53127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      PHA03099
      Location:182271
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
      smart00410
      Location:43129
      IG_like; Immunoglobulin like
      pfam02158
      Location:232421
      Neuregulin; Neuregulin family
    10. XM_012508561.1XP_012364015.1  pro-neuregulin-1, membrane-bound isoform isoform X12

      Conserved Domains (2) summary
      smart00410
      Location:43129
      IG_like; Immunoglobulin like
      cl11960
      Location:53127
      Ig; Immunoglobulin domain
    11. XM_012508562.1XP_012364016.1  pro-neuregulin-1, membrane-bound isoform isoform X13

      Conserved Domains (2) summary
      smart00410
      Location:43129
      IG_like; Immunoglobulin like
      cl11960
      Location:53127
      Ig; Immunoglobulin domain
    12. XM_012508560.1XP_012364014.1  pro-neuregulin-1, membrane-bound isoform isoform X11

      Related
      ENSNLEP00000036805.1, ENSNLET00000034435.1
      Conserved Domains (1) summary
      PHA02887
      Location:236279
      PHA02887; EGF-like protein; Provisional
    13. XM_003269559.2XP_003269607.1  pro-neuregulin-1, membrane-bound isoform isoform X10

      See identical proteins and their annotated locations for XP_003269607.1

      Related
      ENSNLEP00000014653.2, ENSNLET00000015385.2
      Conserved Domains (2) summary
      pfam00008
      Location:3666
      EGF; EGF-like domain
      pfam02158
      Location:81270
      Neuregulin; Neuregulin family
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