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    grb2 growth factor receptor-bound protein 2 [ Ictalurus punctatus (channel catfish) ]

    Gene ID: 100528114, updated on 13-Oct-2018

    Summary

    Gene symbol
    grb2
    Gene description
    growth factor receptor-bound protein 2
    See related
    Ensembl:ENSIPUG00000022848
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Ictalurus punctatus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes; Ictaluridae; Ictalurus

    Genomic context

    See grb2 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    100 current IpCoco_1.2 (GCF_001660625.1) 12 NC_030427.1 (11916006..11923223, complement)

    Chromosome 12 - NC_030427.1Genomic Context describing neighboring genes Neighboring gene SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) Neighboring gene MIF4G domain-containing protein B-like Neighboring gene cilia and flagella associated protein 52 Neighboring gene TBC1 domain family member 24-like

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_030427.1 Chromosome 12 Reference IpCoco_1.2 Primary Assembly

    Pathways from BioSystems

    • Dorso-ventral axis formation, organism-specific biosystem (from KEGG)
      Dorso-ventral axis formation, organism-specific biosystem
      Dorso-ventral axis formation
    • Dorso-ventral axis formation, conserved biosystem (from KEGG)
      Dorso-ventral axis formation, conserved biosystem
      Dorso-ventral axis formation
    • ErbB signaling pathway, organism-specific biosystem (from KEGG)
      ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • ErbB signaling pathway, conserved biosystem (from KEGG)
      ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • FoxO signaling pathway, organism-specific biosystem (from KEGG)
      FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
    • Gap junction, organism-specific biosystem (from KEGG)
      Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
    • Gap junction, conserved biosystem (from KEGG)
      Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
    • GnRH signaling pathway, organism-specific biosystem (from KEGG)
      GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
    • GnRH signaling pathway, conserved biosystem (from KEGG)
      GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
    • Insulin signaling pathway, organism-specific biosystem (from KEGG)
      Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Insulin signaling pathway, conserved biosystem (from KEGG)
      Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • mTOR signaling pathway, organism-specific biosystem (from KEGG)
      mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
    • mTOR signaling pathway, conserved biosystem (from KEGG)
      mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...

    General protein information

    Preferred Names
    growth factor receptor-bound protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001200384.1NP_001187313.1  growth factor receptor-bound protein 2

      See identical proteins and their annotated locations for NP_001187313.1

      Status: PROVISIONAL

      Source sequence(s)
      GU588527
      UniProtKB/TrEMBL
      E3TDU7
      Conserved Domains (3) summary
      cd09941
      Location:56150
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11946
      Location:156
      SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
      cd11949
      Location:160212
      SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

    RefSeqs of Annotated Genomes: Ictalurus punctatus Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference IpCoco_1.2 Primary Assembly

    Genomic

    1. NC_030427.1 Reference IpCoco_1.2 Primary Assembly

      Range
      11916006..11923223 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017480628.1XP_017336117.1  growth factor receptor-bound protein 2 isoform X1

      UniProtKB/TrEMBL
      E3TDU7
      Related
      ENSIPUP00000034017.1, ENSIPUT00000035353.1
      Conserved Domains (3) summary
      cd09941
      Location:56150
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11946
      Location:156
      SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
      cd11949
      Location:160212
      SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
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