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    NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase [ Sus scrofa (pig) ]

    Gene ID: 100512083, updated on 2-Oct-2018

    Summary

    Gene symbol
    NEDD4L
    Gene description
    neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
    See related
    Ensembl:ENSSSCG00000004919
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; Sus
    Expression
    Broad expression in kidney (RPKM 7.0), heart (RPKM 4.2) and 8 other tissues See more
    Orthologs

    Genomic context

    See NEDD4L in Genome Data Viewer
    Location:
    1; 1
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 1 NC_010443.5 (162364053..162736515, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) Unplaced Scaffold NW_003613210.1 (794..31927, complement)

    Chromosome 1 - NC_010443.5Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106509068 Neighboring gene uncharacterized LOC110256838 Neighboring gene alpha kinase 2 Neighboring gene microRNA 122 Neighboring gene uncharacterized LOC102157644 Neighboring gene ATPase phospholipid transporting 8B1 Neighboring gene uncharacterized LOC110261747

    Genomic regions, transcripts, and products

    Expression

    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Pathways from BioSystems

    • Aldosterone-regulated sodium reabsorption, organism-specific biosystem (from KEGG)
      Aldosterone-regulated sodium reabsorption, organism-specific biosystemSodium transport across the tight epithelia of Na+ reabsorbing tissues such as the distal part of the kidney nephron and colon is the major factor determining total-body Na+ levels, and thus, long-te...
    • Aldosterone-regulated sodium reabsorption, conserved biosystem (from KEGG)
      Aldosterone-regulated sodium reabsorption, conserved biosystemSodium transport across the tight epithelia of Na+ reabsorbing tissues such as the distal part of the kidney nephron and colon is the major factor determining total-body Na+ levels, and thus, long-te...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase NEDD4-like

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010443.5 Reference Sscrofa11.1 Primary Assembly

      Range
      162364053..162736515 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021073866.1XP_020929525.1  E3 ubiquitin-protein ligase NEDD4-like isoform X7

      Conserved Domains (6) summary
      cd04033
      Location:21153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:549599
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:660989
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:500530
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:387416
      WW; WW domain
      cl26464
      Location:319502
      Atrophin-1; Atrophin-1 family
    2. XM_021073873.1XP_020929532.1  E3 ubiquitin-protein ligase NEDD4-like isoform X9

      Related
      ENSSSCP00000005294.3, ENSSSCT00000005429.3
      Conserved Domains (5) summary
      cd04033
      Location:21153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:529561
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:622951
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:480510
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:367396
      WW; WW domain
    3. XM_021073871.1XP_020929530.1  E3 ubiquitin-protein ligase NEDD4-like isoform X8

      Related
      ENSSSCP00000034074.1, ENSSSCT00000053523.1
      Conserved Domains (6) summary
      cd04033
      Location:21153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:549581
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:642971
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:500530
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:387416
      WW; WW domain
      cl26464
      Location:319502
      Atrophin-1; Atrophin-1 family
    4. XM_021073898.1XP_020929557.1  E3 ubiquitin-protein ligase NEDD4-like isoform X12

      Related
      ENSSSCP00000035595.1, ENSSSCT00000054104.1
      Conserved Domains (5) summary
      smart00456
      Location:408440
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:501830
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:359389
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:246275
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    5. XM_021073916.1XP_020929575.1  E3 ubiquitin-protein ligase NEDD4-like isoform X13

      Conserved Domains (6) summary
      smart00456
      Location:428478
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:539868
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:379409
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:266295
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
      cl26464
      Location:198381
      Atrophin-1; Atrophin-1 family
    6. XM_021073903.1XP_020929562.1  E3 ubiquitin-protein ligase NEDD4-like isoform X12

      Related
      ENSSSCP00000049986.1, ENSSSCT00000037288.1
      Conserved Domains (5) summary
      smart00456
      Location:408440
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:501830
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:359389
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:246275
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    7. XM_021073884.1XP_020929543.1  E3 ubiquitin-protein ligase NEDD4-like isoform X11

      Conserved Domains (6) summary
      smart00456
      Location:428460
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:521850
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:379409
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:266295
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
      cl26464
      Location:198381
      Atrophin-1; Atrophin-1 family
    8. XM_021073888.1XP_020929547.1  E3 ubiquitin-protein ligase NEDD4-like isoform X11

      Conserved Domains (6) summary
      smart00456
      Location:428460
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:521850
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:379409
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:266295
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
      cl26464
      Location:198381
      Atrophin-1; Atrophin-1 family
    9. XM_021073893.1XP_020929552.1  E3 ubiquitin-protein ligase NEDD4-like isoform X11

      Conserved Domains (6) summary
      smart00456
      Location:428460
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:521850
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:379409
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:266295
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
      cl26464
      Location:198381
      Atrophin-1; Atrophin-1 family
    10. XM_021073879.1XP_020929538.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

      Conserved Domains (6) summary
      smart00456
      Location:492542
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:603932
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:443473
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:330359
      WW; WW domain
      cl14603
      Location:1296
      C2; C2 domain
      cl26464
      Location:262445
      Atrophin-1; Atrophin-1 family
    11. XM_021073911.1XP_020929570.1  E3 ubiquitin-protein ligase NEDD4-like isoform X12

      Conserved Domains (5) summary
      smart00456
      Location:408440
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:501830
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:359389
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:246275
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    12. XM_021073859.1XP_020929518.1  E3 ubiquitin-protein ligase NEDD4-like isoform X5

      Conserved Domains (5) summary
      smart00456
      Location:651701
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:7621091
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:470496
      WW; WW domain
      cl14603
      Location:372425
      C2; C2 domain
      cl25642
      Location:66395
      DUF390; Protein of unknown function (DUF390)
    13. XM_021073862.1XP_020929521.1  E3 ubiquitin-protein ligase NEDD4-like isoform X6

      Conserved Domains (5) summary
      smart00456
      Location:651683
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:7441073
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:470496
      WW; WW domain
      cl14603
      Location:372425
      C2; C2 domain
      cl25642
      Location:66395
      DUF390; Protein of unknown function (DUF390)
    14. XM_021073843.1XP_020929502.1  E3 ubiquitin-protein ligase NEDD4-like isoform X1

      Conserved Domains (6) summary
      smart00456
      Location:821871
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:9321261
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:772802
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:659688
      WW; WW domain
      cl14603
      Location:372425
      C2; C2 domain
      cl25642
      Location:66395
      DUF390; Protein of unknown function (DUF390)
    15. XM_021073849.1XP_020929508.1  E3 ubiquitin-protein ligase NEDD4-like isoform X3

      Related
      ENSSSCP00000048399.1, ENSSSCT00000065789.1
      Conserved Domains (6) summary
      smart00456
      Location:801851
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:9121241
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:752782
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:639668
      WW; WW domain
      cl14603
      Location:372425
      C2; C2 domain
      cl25642
      Location:66395
      DUF390; Protein of unknown function (DUF390)
    16. XM_021073846.1XP_020929505.1  E3 ubiquitin-protein ligase NEDD4-like isoform X2

      Conserved Domains (6) summary
      smart00456
      Location:821853
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:9141243
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:772802
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:659688
      WW; WW domain
      cl14603
      Location:372425
      C2; C2 domain
      cl25642
      Location:66395
      DUF390; Protein of unknown function (DUF390)
    17. XM_021073857.1XP_020929516.1  E3 ubiquitin-protein ligase NEDD4-like isoform X4

      Related
      ENSSSCP00000005293.3, ENSSSCT00000005428.3
      Conserved Domains (6) summary
      smart00456
      Location:801833
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:8941223
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:752782
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:639668
      WW; WW domain
      cl14603
      Location:372425
      C2; C2 domain
      cl25642
      Location:66395
      DUF390; Protein of unknown function (DUF390)
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