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    LAMA3 laminin subunit alpha 3 [ Sus scrofa (pig) ]

    Gene ID: 100511642, updated on 2-Oct-2018

    Summary

    Gene symbol
    LAMA3
    Gene description
    laminin subunit alpha 3
    See related
    Ensembl:ENSSSCG00000003709
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; Sus
    Expression
    Biased expression in lung (RPKM 12.6), ovary (RPKM 7.6) and 3 other tissues See more
    Orthologs

    Genomic context

    See LAMA3 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    77
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 6 NC_010448.4 (108548818..108805700)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 6 NC_010448.3 (101146225..101337451)

    Chromosome 6 - NC_010448.4Genomic Context describing neighboring genes Neighboring gene regulator of MON1-CCZ1 Neighboring gene NPC intracellular cholesterol transporter 1 Neighboring gene ankyrin repeat domain 29 Neighboring gene tetratricopeptide repeat domain 39C Neighboring gene calcium binding tyrosine phosphorylation regulated

    Genomic regions, transcripts, and products

    Expression

    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Amoebiasis, organism-specific biosystem (from KEGG)
      Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Amoebiasis, conserved biosystem (from KEGG)
      Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • ECM-receptor interaction, organism-specific biosystem (from KEGG)
      ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • ECM-receptor interaction, conserved biosystem (from KEGG)
      ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Metabolic pathways, organism-specific biosystem (from KEGG)
      Metabolic pathways, organism-specific biosystem
      Metabolic pathways
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...

    General protein information

    Preferred Names
    laminin subunit alpha-3
    Names
    laminin, alpha 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010448.4 Reference Sscrofa11.1 Primary Assembly

      Range
      108548818..108805700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003482042.4XP_003482090.3  laminin subunit alpha-3 isoform X1

      Related
      ENSSSCP00000004016.3, ENSSSCT00000004108.3
      Conserved Domains (10) summary
      smart00136
      Location:54305
      LamNT; Laminin N-terminal domain (domain VI)
      smart00180
      Location:13671413
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      smart00282
      Location:24462581
      LamG; Laminin G domain
      cd00055
      Location:16971743
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:31703321
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00053
      Location:12771325
      Laminin_EGF; Laminin EGF domain
      pfam06009
      Location:22992427
      Laminin_II; Laminin Domain II
      pfam00052
      Location:15291663
      Laminin_B; Laminin B (Domain IV)
      pfam06008
      Location:18582115
      Laminin_I; Laminin Domain I
      cl25732
      Location:19982309
      SMC_N; RecF/RecN/SMC N terminal domain
    2. XM_021096186.1XP_020951845.1  laminin subunit alpha-3 isoform X2

      Conserved Domains (10) summary
      smart00180
      Location:12191265
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      smart00282
      Location:22982433
      LamG; Laminin G domain
      cd00055
      Location:15491595
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:30223173
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00053
      Location:11291177
      Laminin_EGF; Laminin EGF domain
      pfam06009
      Location:21512279
      Laminin_II; Laminin Domain II
      pfam00052
      Location:13811515
      Laminin_B; Laminin B (Domain IV)
      pfam00055
      Location:9157
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam06008
      Location:17101967
      Laminin_I; Laminin Domain I
      cl25732
      Location:18502161
      SMC_N; RecF/RecN/SMC N terminal domain
    3. XM_003482045.4XP_003482093.2  laminin subunit alpha-3 isoform X3

      Conserved Domains (8) summary
      smart00282
      Location:831966
      LamG; Laminin G domain
      cd00055
      Location:82128
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:15551706
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00053
      Location:130180
      Laminin_EGF; Laminin EGF domain
      pfam06008
      Location:241500
      Laminin_I; Laminin Domain I
      pfam06009
      Location:684812
      Laminin_II; Laminin Domain II
      pfam07926
      Location:451555
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      cl21509
      Location:454573
      ApoLp-III_like; Apolipophorin-III and similar insect proteins
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