Format

Send to:

Choose Destination
    • Showing Current items.

    SLC17A4 solute carrier family 17 member 4 [ Homo sapiens (human) ]

    Gene ID: 10050, updated on 2-Oct-2018

    Summary

    Official Symbol
    SLC17A4provided by HGNC
    Official Full Name
    solute carrier family 17 member 4provided by HGNC
    Primary source
    HGNC:HGNC:10932
    See related
    Ensembl:ENSG00000146039 MIM:604216; Vega:OTTHUMG00000014410
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KAIA2138
    Summary
    Phosphate homeostasis is maintained by regulating intake, intestinal absorption, bone deposition and resorption, and renal excretion of phosphate. The central molecule in the control of phosphate excretion from the kidney is the sodium/phosphate cotransporter NPT1 (SLC17A1; MIM 182308), which is located in the renal proximal tubule. NPT1 uses the transmembrane electrochemical potential gradient of sodium to transport phosphate across the cell membrane. SLC17A4 is a similar sodium/phosphate cotransporter in the intestinal mucosa that plays an important role in the absorption of phosphate from the intestine (summary by Shibui et al., 1999 [PubMed 10319585]).[supplied by OMIM, Feb 2011]
    Expression
    Biased expression in small intestine (RPKM 10.3), duodenum (RPKM 9.0) and 5 other tissues See more
    Orthologs

    Genomic context

    See SLC17A4 in Genome Data Viewer
    Location:
    6p22.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (25754673..25781175)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (25754927..25781403)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene histone cluster 1 H2B pseudogene 1 Neighboring gene solute carrier family 17 member 1 Neighboring gene histone cluster 1 H2A pseudogene 1 Neighboring gene solute carrier family 17 member 3 Neighboring gene histone cluster 1 H2A pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Phenotypes

    NHGRI GWAS Catalog

    Description
    An atlas of genetic influences on human blood metabolites.
    NHGRI GWA Catalog
    Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
    NHGRI GWA Catalog
    Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque.
    NHGRI GWA Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of solute carrier family 17 (sodium phosphate), member 4 (SLC17A4; KAIA2138) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA2138, MGC129623

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    sialic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sodium:phosphate symporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    phosphate-containing compound metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    sialic acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    sodium ion transport TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    probable small intestine urate exporter
    Names
    Na/PO4 cotransporter
    putative small intestine sodium-dependent phosphate transport protein
    solute carrier family 17 (sodium phosphate), member 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286121.1NP_001273050.1  probable small intestine urate exporter isoform b

      See identical proteins and their annotated locations for NP_001273050.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in its 5' UTR and initiaties translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AK024903, AL391194, BC109208
      Consensus CDS
      CCDS75411.1
      UniProtKB/Swiss-Prot
      Q9Y2C5
      Related
      ENSP00000391345.3, ENST00000439485.6
      Conserved Domains (1) summary
      cl27298
      Location:1437
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]
    2. NM_005495.2NP_005486.1  probable small intestine urate exporter isoform a

      See identical proteins and their annotated locations for NP_005486.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (a).
      Source sequence(s)
      AB020527, AL391194
      Consensus CDS
      CCDS4564.1
      UniProtKB/Swiss-Prot
      Q9Y2C5
      UniProtKB/TrEMBL
      A0A024R013
      Related
      ENSP00000367137.4, OTTHUMP00000016125, ENST00000377905.8, OTTHUMT00000040068
      Conserved Domains (1) summary
      cl27298
      Location:30491
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

      Range
      25754673..25781175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011514213.2XP_011512515.1  probable small intestine urate exporter isoform X3

      Conserved Domains (2) summary
      cd06174
      Location:98402
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00894
      Location:30413
      2A0114euk; Na(+)-dependent inorganic phosphate cotransporter
    2. XM_011514217.2XP_011512519.1  probable small intestine urate exporter isoform X7

      Conserved Domains (1) summary
      cd06174
      Location:117304
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    3. XM_011514219.2XP_011512521.1  probable small intestine urate exporter isoform X9

      UniProtKB/Swiss-Prot
      Q9Y2C5
      Conserved Domains (1) summary
      cd06174
      Location:88250
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    4. XM_017010150.1XP_016865639.1  probable small intestine urate exporter isoform X4

    5. XM_011514214.2XP_011512516.1  probable small intestine urate exporter isoform X5

      Conserved Domains (1) summary
      cd06174
      Location:98334
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    6. XM_017010151.1XP_016865640.1  probable small intestine urate exporter isoform X10

    7. XM_011514215.2XP_011512517.1  probable small intestine urate exporter isoform X6

      Conserved Domains (1) summary
      cd06174
      Location:98330
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    8. XM_024446297.1XP_024302065.1  probable small intestine urate exporter isoform X2

      Conserved Domains (1) summary
      cl27298
      Location:1437
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]
    9. XM_024446295.1XP_024302063.1  probable small intestine urate exporter isoform X1

      Conserved Domains (1) summary
      cl27298
      Location:30491
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]
    10. XM_024446296.1XP_024302064.1  probable small intestine urate exporter isoform X1

      Conserved Domains (1) summary
      cl27298
      Location:30491
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]
    11. XM_024446294.1XP_024302062.1  probable small intestine urate exporter isoform X1

      Conserved Domains (1) summary
      cl27298
      Location:30491
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]
    12. XM_011514211.1XP_011512513.1  probable small intestine urate exporter isoform X2

      See identical proteins and their annotated locations for XP_011512513.1

      UniProtKB/Swiss-Prot
      Q9Y2C5
      Conserved Domains (1) summary
      cl27298
      Location:1437
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]
    13. XM_011514218.2XP_011512520.1  probable small intestine urate exporter isoform X8

      Conserved Domains (1) summary
      cd06174
      Location:2272
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    RNA

    1. XR_925997.1 RNA Sequence

    2. XR_925996.1 RNA Sequence

    3. XR_925998.1 RNA Sequence

    4. XR_925999.1 RNA Sequence

    Support Center