cln8 CLN8, transmembrane ER and ERGIC protein [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: cln8provided by Xenbase
Official Full Name: CLN8, transmembrane ER and ERGIC proteinprovided by Xenbase
Primary source: Xenbase:XB-GENE-952651
See related: Ensembl:ENSXETG00000037255 AllianceGenome:Xenbase:XB-GENE-952651
Gene type: protein coding
RefSeq status: MODEL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: mnd; epmr
Summary: Predicted to enable ceramide binding activity. Predicted to be involved in lipid homeostasis; nervous system development; and phospholipid metabolic process. Predicted to act upstream of or within several processes, including action potential initiation; locomotory exploration behavior; and social behavior. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 8 and neuronal ceroid lipofuscinosis 8 northern epilepsy variant. Orthologous to human CLN8 (CLN8 transmembrane ER and ERGIC protein). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	5	NC_030681.2 (98720431..98724503, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	5	NC_030681.1 (112256929..112260174)

Chromosome 5 - NC_030681.2 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables ceramide binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within action potential initiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within aggressive behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cognition	IEA Inferred from Electronic Annotation more info
involved_in lipid homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within locomotory exploration behavior	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of autophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within social behavior	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info