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    MSH6 mutS homolog 6 [ Pongo abelii (Sumatran orangutan) ]

    Gene ID: 100458732, updated on 9-Oct-2018

    Summary

    Gene symbol
    MSH6
    Gene description
    mutS homolog 6
    Locus tag
    CR201_G0003433
    See related
    Ensembl:ENSPPYG00000012425
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pongo abelii
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
    Orthologs

    Genomic context

    See MSH6 in Genome Data Viewer
    Location:
    chromosome: 2A
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    103 current Susie_PABv2 (GCF_002880775.1) 2A NC_036904.1 (60864966..60889887, complement)
    102 previous assembly P_pygmaeus_2.0.2 (GCF_000001545.4) 2A NC_012592.1 (63518836..63544066, complement)

    Chromosome 2A - NC_036904.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-40S ribosomal protein S27a pseudogene Neighboring gene F-box protein 11 Neighboring gene U6 spliceosomal RNA Neighboring gene nucleoside diphosphate kinase B-like Neighboring gene small nucleolar RNA U3

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem (from KEGG)
      BRCA1-associated genome surveillance complex (BASC), organism-specific biosystemStructural complex; Genetic information processing; Repair system
    • BRCA1-associated genome surveillance complex (BASC), conserved biosystem (from KEGG)
      BRCA1-associated genome surveillance complex (BASC), conserved biosystemStructural complex; Genetic information processing; Repair system
    • Colorectal cancer, organism-specific biosystem (from KEGG)
      Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Colorectal cancer, conserved biosystem (from KEGG)
      Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Mismatch repair, organism-specific biosystem (from KEGG)
      Mismatch repair, organism-specific biosystemDNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preven...
    • Mismatch repair, conserved biosystem (from KEGG)
      Mismatch repair, conserved biosystemDNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preven...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Platinum drug resistance, organism-specific biosystem (from KEGG)
      Platinum drug resistance, organism-specific biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. T...
    • Platinum drug resistance, conserved biosystem (from KEGG)
      Platinum drug resistance, conserved biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. T...

    General gene information

    Markers

    General protein information

    Preferred Names
    DNA mismatch repair protein Msh6

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Pongo abelii Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Susie_PABv2 Primary Assembly

    Genomic

    1. NC_036904.1 Reference Susie_PABv2 Primary Assembly

      Range
      60864966..60889887 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002812046.4XP_002812092.2  DNA mismatch repair protein Msh6

      Conserved Domains (2) summary
      cd05837
      Location:90197
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      COG0249
      Location:4091327
      MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
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