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    C1S complement C1s [ Pongo abelii (Sumatran orangutan) ]

    Gene ID: 100455685, updated on 9-Oct-2018

    Summary

    Gene symbol
    C1S
    Gene description
    complement C1s
    Locus tag
    CR201_G0036302
    See related
    Ensembl:ENSPPYG00000004217
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pongo abelii
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
    Orthologs

    Genomic context

    See C1S in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    103 current Susie_PABv2 (GCF_002880775.1) 12 NC_036915.1 (7087578..7098138)
    102 previous assembly P_pygmaeus_2.0.2 (GCF_000001545.4) 12 NC_012603.1 (7295038..7305782)

    Chromosome 12 - NC_036915.1Genomic Context describing neighboring genes Neighboring gene lysophosphatidylcholine acyltransferase 3 Neighboring gene zinc finger protein 311-like Neighboring gene complement C1r subcomponent-like Neighboring gene complement C1r Neighboring gene complement C1s subcomponent-like

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    • Complement and coagulation cascades, organism-specific biosystem (from KEGG)
      Complement and coagulation cascades, organism-specific biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
    • Complement and coagulation cascades, conserved biosystem (from KEGG)
      Complement and coagulation cascades, conserved biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
    • Pertussis, organism-specific biosystem (from KEGG)
      Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Pertussis, conserved biosystem (from KEGG)
      Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Staphylococcus aureus infection, organism-specific biosystem (from KEGG)
      Staphylococcus aureus infection, organism-specific biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    • Staphylococcus aureus infection, conserved biosystem (from KEGG)
      Staphylococcus aureus infection, conserved biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    • Systemic lupus erythematosus, organism-specific biosystem (from KEGG)
      Systemic lupus erythematosus, organism-specific biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
    • Systemic lupus erythematosus, conserved biosystem (from KEGG)
      Systemic lupus erythematosus, conserved biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    complement C1s subcomponent

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Pongo abelii Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Susie_PABv2 Primary Assembly

    Genomic

    1. NC_036915.1 Reference Susie_PABv2 Primary Assembly

      Range
      7087578..7098138
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002822843.4XP_002822889.1  complement C1s subcomponent

      See identical proteins and their annotated locations for XP_002822889.1

      UniProtKB/TrEMBL
      H2NGB6
      Related
      ENSPPYP00000004806
      Conserved Domains (6) summary
      cd00033
      Location:294355
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:359421
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      cd00041
      Location:18129
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00190
      Location:438678
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00431
      Location:175287
      CUB; CUB domain
      pfam14670
      Location:143171
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    2. XM_002822842.4XP_002822888.1  complement C1s subcomponent

      See identical proteins and their annotated locations for XP_002822888.1

      UniProtKB/TrEMBL
      H2NGB6
      Conserved Domains (6) summary
      cd00033
      Location:294355
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:359421
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      cd00041
      Location:18129
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00190
      Location:438678
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00431
      Location:175287
      CUB; CUB domain
      pfam14670
      Location:143171
      FXa_inhibition; Coagulation Factor Xa inhibitory site
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