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    ATM ATM serine/threonine kinase [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 100427400, updated on 29-Apr-2017

    Summary

    Gene symbol
    ATM
    Gene description
    ATM serine/threonine kinase
    See related
    Ensembl:ENSMMUG00000004153
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs

    Genomic context

    See ATM in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    68
    Annotation release Status Assembly Chr Location
    102 current Mmul_8.0.1 (GCF_000772875.2) 14 NC_027906.1 (101149343..101283107)
    Build 1.2 previous assembly Mmul_051212 (GCF_000002255.3) 14 NC_007871.1 (106806863..106933298)

    Chromosome 14 - NC_027906.1Genomic Context describing neighboring genes Neighboring gene acetyl-CoA acetyltransferase 1 Neighboring gene nuclear protein, ataxia-telangiectasia locus Neighboring gene chromosome 14 open reading frame, human C11orf65 Neighboring gene KDEL motif containing 2 Neighboring gene exophilin 5

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem (from KEGG)
      BRCA1-associated genome surveillance complex (BASC), organism-specific biosystemStructural complex; Genetic information processing; Repair system
    • BRCA1-associated genome surveillance complex (BASC), conserved biosystem (from KEGG)
      BRCA1-associated genome surveillance complex (BASC), conserved biosystemStructural complex; Genetic information processing; Repair system
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • DNA damage-induced cell cycle checkpoints, organism-specific biosystem (from KEGG)
      DNA damage-induced cell cycle checkpoints, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
    • DNA damage-induced cell cycle checkpoints, conserved biosystem (from KEGG)
      DNA damage-induced cell cycle checkpoints, conserved biosystemFunctional set; Cellular processes; Cell signaling
    • FoxO signaling pathway, organism-specific biosystem (from KEGG)
      FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Homologous recombination, organism-specific biosystem (from KEGG)
      Homologous recombination, organism-specific biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
    • Homologous recombination, conserved biosystem (from KEGG)
      Homologous recombination, conserved biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
    • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
      MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • MicroRNAs in cancer, conserved biosystem (from KEGG)
      MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
      NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • NF-kappa B signaling pathway, conserved biosystem (from KEGG)
      NF-kappa B signaling pathway, conserved biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • Platinum drug resistance, organism-specific biosystem (from KEGG)
      Platinum drug resistance, organism-specific biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. T...
    • Platinum drug resistance, conserved biosystem (from KEGG)
      Platinum drug resistance, conserved biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. T...
    • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
      Transcriptional misregulation in cancer, organism-specific biosystem
      Transcriptional misregulation in cancer
    • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
      Transcriptional misregulation in cancer, conserved biosystem
      Transcriptional misregulation in cancer
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    serine-protein kinase ATM
    Names
    ataxia telangiectasia mutated
    XP_014971094.1
    XP_014971095.1
    XP_014971096.1
    XP_014971098.1
    XP_014971099.1
    XP_014971100.1
    XP_014971101.1
    XP_014971102.1
    XP_014971103.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_8.0.1 Primary Assembly

    Genomic

    1. NC_027906.1 Reference Mmul_8.0.1 Primary Assembly

      Range
      101149343..101283107
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015115608.1XP_014971094.1  serine-protein kinase ATM isoform X1

      UniProtKB/TrEMBL
      F6ZIB3
      Related
      ENSMMUP00000036720.2, ENSMMUT00000043730.2
      Conserved Domains (4) summary
      cd05171
      Location:26832962
      PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated
      pfam02259
      Location:20962489
      FAT; FAT domain
      pfam02260
      Location:30263055
      FATC; FATC domain
      pfam11640
      Location:11165
      TAN; Telomere-length maintenance and DNA damage repair
    2. XM_015115609.1XP_014971095.1  serine-protein kinase ATM isoform X1

      UniProtKB/TrEMBL
      F6ZIB3
      Conserved Domains (4) summary
      cd05171
      Location:26832962
      PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated
      pfam02259
      Location:20962489
      FAT; FAT domain
      pfam02260
      Location:30263055
      FATC; FATC domain
      pfam11640
      Location:11165
      TAN; Telomere-length maintenance and DNA damage repair
    3. XM_015115610.1XP_014971096.1  serine-protein kinase ATM isoform X1

      UniProtKB/TrEMBL
      F6ZIB3
      Conserved Domains (4) summary
      cd05171
      Location:26832962
      PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated
      pfam02259
      Location:20962489
      FAT; FAT domain
      pfam02260
      Location:30263055
      FATC; FATC domain
      pfam11640
      Location:11165
      TAN; Telomere-length maintenance and DNA damage repair
    4. XM_015115615.1XP_014971101.1  serine-protein kinase ATM isoform X2

      Conserved Domains (4) summary
      cd05171
      Location:26282907
      PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated
      pfam02259
      Location:20412434
      FAT; FAT domain
      pfam02260
      Location:29713000
      FATC; FATC domain
      pfam11640
      Location:11165
      TAN; Telomere-length maintenance and DNA damage repair
    5. XM_015115616.1XP_014971102.1  serine-protein kinase ATM isoform X3

      Conserved Domains (3) summary
      cd05171
      Location:26832929
      PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated
      pfam02259
      Location:20962489
      FAT; FAT domain
      pfam11640
      Location:11165
      TAN; Telomere-length maintenance and DNA damage repair
    6. XM_015115617.1XP_014971103.1  serine-protein kinase ATM isoform X4

      Conserved Domains (3) summary
      pfam02259
      Location:20962489
      FAT; FAT domain
      pfam11640
      Location:11165
      TAN; Telomere-length maintenance and DNA damage repair
      cl21453
      Location:26832806
      PKc_like; Protein Kinases, catalytic domain
    7. XM_015115613.1XP_014971099.1  serine-protein kinase ATM isoform X1

      UniProtKB/TrEMBL
      F6ZIB3
      Conserved Domains (4) summary
      cd05171
      Location:26832962
      PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated
      pfam02259
      Location:20962489
      FAT; FAT domain
      pfam02260
      Location:30263055
      FATC; FATC domain
      pfam11640
      Location:11165
      TAN; Telomere-length maintenance and DNA damage repair
    8. XM_015115614.1XP_014971100.1  serine-protein kinase ATM isoform X1

      UniProtKB/TrEMBL
      F6ZIB3
      Related
      ENSMMUP00000005561.3, ENSMMUT00000005904.3
      Conserved Domains (4) summary
      cd05171
      Location:26832962
      PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated
      pfam02259
      Location:20962489
      FAT; FAT domain
      pfam02260
      Location:30263055
      FATC; FATC domain
      pfam11640
      Location:11165
      TAN; Telomere-length maintenance and DNA damage repair
    9. XM_015115612.1XP_014971098.1  serine-protein kinase ATM isoform X1

      UniProtKB/TrEMBL
      F6ZIB3
      Conserved Domains (4) summary
      cd05171
      Location:26832962
      PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated
      pfam02259
      Location:20962489
      FAT; FAT domain
      pfam02260
      Location:30263055
      FATC; FATC domain
      pfam11640
      Location:11165
      TAN; Telomere-length maintenance and DNA damage repair
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