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    PEG10 paternally expressed 10 [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100352080, updated on 8-Apr-2017

    Summary

    Gene symbol
    PEG10
    Gene description
    paternally expressed 10
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Summary
    This gene is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation, apoptosis and cancer development. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2014]
    Orthologs

    Genomic context

    See PEG10 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    102 current OryCun2.0 (GCF_000003625.3) 10 NC_013678.1 (34274046..34286558, complement)

    Chromosome 10 - NC_013678.1Genomic Context describing neighboring genes Neighboring gene paraoxonase 1 Neighboring gene protein phosphatase 1 regulatory subunit 9A Neighboring gene sarcoglycan epsilon Neighboring gene CAS1 domain containing 1

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_013678.1 Chromosome 10 Reference OryCun2.0 Primary Assembly

    General protein information

    Preferred Names
    retrotransposon-derived protein PEG10

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001292089.2NP_001279018.1  retrotransposon-derived protein PEG10 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) has two overlapping open reading frames (RFI and RF2). This isoform (1) is derived from RF1/RF2 by -1 translational frameshifting.
      Source sequence(s)
      AAGW02035426, GBCH01045805, GBCK01063295, GBCN01068021, GBCN01068022, GBCT01002089, GBCT01004458
      Conserved Domains (4) summary
      cd00303
      Location:402486
      retropepsin_like; Retropepsins; pepsin-like aspartate proteases
      smart00338
      Location:3782
      BRLZ; basic region leucin zipper
      pfam03732
      Location:156249
      Retrotrans_gag; Retrotransposon gag protein
      pfam16297
      Location:115195
      DUF4939; Domain of unknown function (DUF4939)
    2. NM_001292090.2NP_001279019.1  retrotransposon-derived protein PEG10 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) has two overlapping open reading frames (RFI and RF2). This isoform (2) produced from RF1 in the absence of -1 translational frameshifting has a shorter C-terminus compared to isoform 1.
      Source sequence(s)
      AAGW02035426, GBCH01045805, GBCK01063295, GBCN01068021, GBCN01068022, GBCT01002089, GBCT01004458
      Conserved Domains (3) summary
      pfam03732
      Location:156249
      Retrotrans_gag; Retrotransposon gag protein
      pfam16297
      Location:115195
      DUF4939; Domain of unknown function (DUF4939)
      cl21462
      Location:4582
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    3. NM_001302483.1NP_001289412.1  retrotransposon-derived protein PEG10 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has two overlapping open reading frames (RF1 and RF2). It uses an alternate donor splice site at the 5' terminal exon and initiates translation from an alternate, upstream AUG compared to variant 1. This isoform (3) derived from RF1/RF2 by -1 translational frameshifting has a longer and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AAGW02035426, GBCH01045805, GBCK01063294, GBCN01068021, GBCN01068022, GBCT01002089, GBCT01004458
      Conserved Domains (4) summary
      cd00303
      Location:448532
      retropepsin_like; Retropepsins; pepsin-like aspartate proteases
      smart00338
      Location:83128
      BRLZ; basic region leucin zipper
      pfam03732
      Location:202295
      Retrotrans_gag; Retrotransposon gag protein
      pfam16297
      Location:161241
      DUF4939; Domain of unknown function (DUF4939)
    4. NM_001302484.1NP_001289413.1  retrotransposon-derived protein PEG10 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has two overlapping open reading frames (RF1 and RF2). It uses an alternate donor splice site at the 5' terminal exon and initiates translation from an alternate, upstream AUG compared to variant 1. This isoform (4) produced from RF1 in the absence of -1 translational frameshifting has a longer and distinct N-terminus, but a shorter C-terminus compared to isoform 1.
      Source sequence(s)
      AAGW02035426, GBCH01045805, GBCK01063294, GBCN01068021, GBCN01068022, GBCT01002089, GBCT01004458
      Conserved Domains (3) summary
      pfam03732
      Location:202295
      Retrotrans_gag; Retrotransposon gag protein
      pfam16297
      Location:161241
      DUF4939; Domain of unknown function (DUF4939)
      cl21462
      Location:91128
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: Oryctolagus cuniculus Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference OryCun2.0 Primary Assembly

    Genomic

    1. NC_013678.1 Reference OryCun2.0 Primary Assembly

      Range
      34274046..34286558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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