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    F8 coagulation factor VIII [ Bos taurus (cattle) ]

    Gene ID: 100271720, updated on 27-Aug-2018

    Summary

    Official Symbol
    F8provided by VGNC
    Official Full Name
    coagulation factor VIIIprovided by VGNC
    Primary source
    VGNC:VGNC:28690
    See related
    Ensembl:ENSBTAG00000010726
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs

    Genomic context

    Location:
    chromosome: X
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) X NC_037357.1 (36013125..36155734)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) X AC_000187.1 (38838455..38982287)

    Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene BRCA1/BRCA2-containing complex subunit 3 Neighboring gene C-X9-C motif containing 4 Neighboring gene mature T cell proliferation 1 Neighboring gene FUN14 domain containing 2 Neighboring gene small nucleolar RNA SNORA25 Neighboring gene histone H2A-Bbd type 2/3 Neighboring gene coagulation factor VIII associated 1 Neighboring gene small integral membrane protein 9 Neighboring gene membrane palmitoylated protein 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    coagulation factor VIII
    Names
    coagulation factor VIII, procoagulant component
    factor VIII

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145508.1NP_001138980.1  coagulation factor VIII precursor

      See identical proteins and their annotated locations for NP_001138980.1

      Status: PROVISIONAL

      Source sequence(s)
      AB485748
      UniProtKB/TrEMBL
      B9X245
      Related
      ENSBTAP00000036581.4, ENSBTAT00000036726.4
      Conserved Domains (5) summary
      smart00231
      Location:20112160
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:21672316
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd04227
      Location:394570
      CuRO_3_FVIII_like; The third cupredoxin domain of coagulation factor VIII and similar proteins
      cd14452
      Location:22202
      CuRO_1_FVIII_like; The first cupredoxin domain of coagulation factor VIII and similar proteins
      cl19115
      Location:16861850
      Cupredoxin; Cupredoxin superfamily

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037357.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      36013125..36155734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024987718.1XP_024843486.1  coagulation factor VIII isoform X2

      Conserved Domains (3) summary
      cd00057
      Location:21432292
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd04227
      Location:370546
      CuRO_3_FVIII_like; The third cupredoxin domain of coagulation factor VIII and similar proteins
      cl19115
      Location:16621826
      Cupredoxin; Cupredoxin superfamily
    2. XM_024987717.1XP_024843485.1  coagulation factor VIII isoform X1

      Conserved Domains (4) summary
      cd00057
      Location:21672316
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd04227
      Location:394570
      CuRO_3_FVIII_like; The third cupredoxin domain of coagulation factor VIII and similar proteins
      cd14452
      Location:22202
      CuRO_1_FVIII_like; The first cupredoxin domain of coagulation factor VIII and similar proteins
      cl19115
      Location:16861850
      Cupredoxin; Cupredoxin superfamily
    3. XM_005227639.4XP_005227696.1  coagulation factor VIII isoform X1

      See identical proteins and their annotated locations for XP_005227696.1

      UniProtKB/TrEMBL
      G5E5W1
      Conserved Domains (4) summary
      cd00057
      Location:21672316
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd04227
      Location:394570
      CuRO_3_FVIII_like; The third cupredoxin domain of coagulation factor VIII and similar proteins
      cd14452
      Location:22202
      CuRO_1_FVIII_like; The first cupredoxin domain of coagulation factor VIII and similar proteins
      cl19115
      Location:16861850
      Cupredoxin; Cupredoxin superfamily
    4. XM_024987720.1XP_024843488.1  coagulation factor VIII isoform X4

      Conserved Domains (2) summary
      cd04227
      Location:394570
      CuRO_3_FVIII_like; The third cupredoxin domain of coagulation factor VIII and similar proteins
      cl19115
      Location:22202
      Cupredoxin; Cupredoxin superfamily
    5. XM_024987719.1XP_024843487.1  coagulation factor VIII isoform X3

      Conserved Domains (3) summary
      cd00057
      Location:21032252
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd04227
      Location:330506
      CuRO_3_FVIII_like; The third cupredoxin domain of coagulation factor VIII and similar proteins
      cl19115
      Location:16221786
      Cupredoxin; Cupredoxin superfamily
    6. XM_024987721.1XP_024843489.1  coagulation factor VIII isoform X5

      Conserved Domains (1) summary
      cd00057
      Location:98247
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    RNA

    1. XR_001495546.2 RNA Sequence

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