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    PTPN1 protein tyrosine phosphatase, non-receptor type 1 [ Pongo abelii (Sumatran orangutan) ]

    Gene ID: 100172151, updated on 7-Oct-2018

    Summary

    Gene symbol
    PTPN1
    Gene description
    protein tyrosine phosphatase, non-receptor type 1
    Locus tag
    CR201_G0043618
    See related
    Ensembl:ENSPPYG00000011126
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pongo abelii
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
    Orthologs

    Genomic context

    See PTPN1 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    103 current Susie_PABv2 (GCF_002880775.1) 20 NC_036923.1 (46984724..47060425)
    102 previous assembly P_pygmaeus_2.0.2 (GCF_000001545.4) 20 NC_012611.1 (48261293..48319676) , (48327818..48337853)

    Chromosome 20 - NC_036923.1Genomic Context describing neighboring genes Neighboring gene CCAAT enhancer binding protein beta Neighboring gene small integral membrane protein 25 Neighboring gene 60S ribosomal protein L36 pseudogene Neighboring gene RIPOR family member 3 Neighboring gene uncharacterized LOC103888826

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Adherens junction, organism-specific biosystem (from KEGG)
      Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junction, conserved biosystem (from KEGG)
      Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Insulin resistance, organism-specific biosystem (from KEGG)
      Insulin resistance, organism-specific biosystemInsulin resistance is a condition where cells become resistant to the effects of insulin. It is often found in people with health disorders, including obesity, type 2 diabetes mellitus, non-alcoholic...
    • Insulin signaling pathway, organism-specific biosystem (from KEGG)
      Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Insulin signaling pathway, conserved biosystem (from KEGG)
      Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp469N1518

    General protein information

    Preferred Names
    tyrosine-protein phosphatase non-receptor type 1
    NP_001125254.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001131782.1NP_001125254.1  tyrosine-protein phosphatase non-receptor type 1

      See identical proteins and their annotated locations for NP_001125254.1

      Status: PROVISIONAL

      Source sequence(s)
      CR858250
      UniProtKB/TrEMBL
      Q5RCM0
      Related
      ENSPPYP00000012433, ENSPPYT00000012921
      Conserved Domains (2) summary
      smart00194
      Location:3276
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:43276
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: Pongo abelii Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Susie_PABv2 Primary Assembly

    Genomic

    1. NC_036923.1 Reference Susie_PABv2 Primary Assembly

      Range
      46984724..47060425
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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