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    OAZ3 ornithine decarboxylase antizyme 3 [ Equus caballus (horse) ]

    Gene ID: 100055594, updated on 14-Jan-2019

    Summary

    Official Symbol
    OAZ3provided by VGNC
    Official Full Name
    ornithine decarboxylase antizyme 3provided by VGNC
    Primary source
    VGNC:VGNC:20999
    See related
    Ensembl:ENSECAG00000015002
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Summary
    The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake, however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies in mice showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. This transcript initiates translation from a non-AUG (CUG) start codon that is highly conserved amongst the antizyme 3 orthologs. [provided by RefSeq, Aug 2014]
    Orthologs

    Genomic context

    See OAZ3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    103 current EquCab3.0 (GCF_002863925.1) 5 NC_009148.3 (42162694..42165844, complement)
    102 previous assembly EquCab2.0 (GCF_000002305.2) 5 NC_009148.2 (45549809..45552959, complement)

    Chromosome 5 - NC_009148.3Genomic Context describing neighboring genes Neighboring gene leucine rich repeat and Ig domain containing 4 Neighboring gene tudor and KH domain containing Neighboring gene microRNA mir-7045 Neighboring gene regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1

    Genomic regions, transcripts, and products

    General protein information

    Preferred Names
    ornithine decarboxylase antizyme 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172714.1NP_001166185.1  ornithine decarboxylase antizyme 3

      Status: REVIEWED

      Source sequence(s)
      PJAA01000006
      Related
      ENSECAP00000012663.2, ENSECAT00000015723.2
      Conserved Domains (1) summary
      pfam02100
      Location:131222
      ODC_AZ; Ornithine decarboxylase antizyme

    RefSeqs of Annotated Genomes: Equus caballus Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009148.3 Reference EquCab3.0 Primary Assembly

      Range
      42162694..42165844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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