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    MAP3K2 mitogen-activated protein kinase kinase kinase 2 [ Equus caballus (horse) ]

    Gene ID: 100050628, updated on 26-Sep-2018

    Summary

    Official Symbol
    MAP3K2provided by VGNC
    Official Full Name
    mitogen-activated protein kinase kinase kinase 2provided by VGNC
    Primary source
    VGNC:VGNC:19936
    See related
    Ensembl:ENSECAG00000021505
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs

    Genomic context

    See MAP3K2 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    103 current EquCab3.0 (GCF_002863925.1) 18 NC_009161.3 (3508539..3597259)
    102 previous assembly EquCab2.0 (GCF_000002305.2) 18 NC_009161.2 (3599274..3629582)

    Chromosome 18 - NC_009161.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111768865 Neighboring gene uncharacterized LOC111768864 Neighboring gene protein C, inactivator of coagulation factors Va and VIIIa Neighboring gene ERCC excision repair 3, TFIIH core complex helicase subunit Neighboring gene cytochrome P450 family 27 subfamily C member 1

    Genomic regions, transcripts, and products

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Gap junction, organism-specific biosystem (from KEGG)
      Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
    • Gap junction, conserved biosystem (from KEGG)
      Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
    • GnRH signaling pathway, organism-specific biosystem (from KEGG)
      GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
    • GnRH signaling pathway, conserved biosystem (from KEGG)
      GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
    • MAPK (ERK5) signaling, organism-specific biosystem (from KEGG)
      MAPK (ERK5) signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
    • MAPK (ERK5) signaling, conserved biosystem (from KEGG)
      MAPK (ERK5) signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
    • MAPK (JNK) signaling, organism-specific biosystem (from KEGG)
      MAPK (JNK) signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
    • MAPK (JNK) signaling, conserved biosystem (from KEGG)
      MAPK (JNK) signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
    • MAPK (p38) signaling, organism-specific biosystem (from KEGG)
      MAPK (p38) signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
    • MAPK (p38) signaling, conserved biosystem (from KEGG)
      MAPK (p38) signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...

    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase kinase 2
    NP_001296183.1
    XP_023477730.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309254.1NP_001296183.1  mitogen-activated protein kinase kinase kinase 2

      See identical proteins and their annotated locations for NP_001296183.1

      Status: PROVISIONAL

      Source sequence(s)
      PJAA01000019
      Related
      ENSECAP00000019177.1, ENSECAT00000023172.1
      Conserved Domains (2) summary
      cd06405
      Location:44122
      PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
      cd06652
      Location:353616
      STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

    RefSeqs of Annotated Genomes: Equus caballus Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009161.3 Reference EquCab3.0 Primary Assembly

      Range
      3508539..3597259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023621962.1XP_023477730.1  mitogen-activated protein kinase kinase kinase 2 isoform X1

      Conserved Domains (2) summary
      cd06405
      Location:44122
      PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
      cd06652
      Location:353616
      STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2
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