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    JAG2 jagged canonical Notch ligand 2 [ Monodelphis domestica (gray short-tailed opossum) ]

    Gene ID: 100014054, updated on 17-Apr-2019

    Summary

    Gene symbol
    JAG2
    Gene description
    jagged canonical Notch ligand 2
    See related
    Ensembl:ENSMODG00000014707
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Monodelphis domestica
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis
    Orthologs

    Genomic context

    See JAG2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    103 current MonDom5 (GCF_000002295.2) 1 NC_008801.1 (295476377..295630950, complement)

    Chromosome 1 - NC_008801.1Genomic Context describing neighboring genes Neighboring gene kinetochore protein Nuf2 pseudogene Neighboring gene G protein-coupled receptor 132 Neighboring gene uncharacterized LOC107650547 Neighboring gene uncharacterized LOC103097674 Neighboring gene small integral membrane protein 1-like Neighboring gene proline synthase co-transcribed bacterial homolog protein pseudogene

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_008801.1 Chromosome 1 Reference MonDom5 Primary Assembly

    Pathways from BioSystems

    • Apelin signaling pathway, organism-specific biosystem (from KEGG)
      Apelin signaling pathway, organism-specific biosystemApelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various ti...
    • Breast cancer, organism-specific biosystem (from KEGG)
      Breast cancer, organism-specific biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
    • Breast cancer, conserved biosystem (from KEGG)
      Breast cancer, conserved biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
    • Endocrine resistance, organism-specific biosystem (from KEGG)
      Endocrine resistance, organism-specific biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
    • Endocrine resistance, conserved biosystem (from KEGG)
      Endocrine resistance, conserved biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
    • Notch signaling pathway, organism-specific biosystem (from KEGG)
      Notch signaling pathway, organism-specific biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
    • Notch signaling pathway, conserved biosystem (from KEGG)
      Notch signaling pathway, conserved biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
    • Th1 and Th2 cell differentiation, organism-specific biosystem (from KEGG)
      Th1 and Th2 cell differentiation, organism-specific biosystemImmunity to different classes of microorganisms is orchestrated by separate lineages of effector T helper (TH)-cells, which differentiate from naive CD4+ precursor cells in response to cues provided ...
    • Th1 and Th2 cell differentiation, conserved biosystem (from KEGG)
      Th1 and Th2 cell differentiation, conserved biosystemImmunity to different classes of microorganisms is orchestrated by separate lineages of effector T helper (TH)-cells, which differentiate from naive CD4+ precursor cells in response to cues provided ...

    General protein information

    Preferred Names
    protein jagged-2
    Names
    jagged 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Monodelphis domestica Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference MonDom5 Primary Assembly

    Genomic

    1. NC_008801.1 Reference MonDom5 Primary Assembly

      Range
      295476377..295630950 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_007473314.2XP_007473376.1  protein jagged-2 isoform X2

      Conserved Domains (5) summary
      smart00215
      Location:834905
      VWC_out; von Willebrand factor (vWF) type C domain
      cd00054
      Location:307345
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:678708
      EGF; EGF-like domain
      pfam01414
      Location:178240
      DSL; Delta serrate ligand
      pfam07657
      Location:29106
      MNNL; N terminus of Notch ligand
    2. XM_001368356.4XP_001368393.2  protein jagged-2 isoform X1

      UniProtKB/TrEMBL
      F7D3A1
      Related
      ENSMODP00000018384.3, ENSMODT00000018717.3
      Conserved Domains (5) summary
      smart00215
      Location:872943
      VWC_out; von Willebrand factor (vWF) type C domain
      cd00054
      Location:307345
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:716746
      EGF; EGF-like domain
      pfam01414
      Location:178240
      DSL; Delta serrate ligand
      pfam07657
      Location:29106
      MNNL; N terminus of Notch ligand
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