Format

Send to:

Choose Destination
    • Showing Current items.

    MMP14 matrix metallopeptidase 14 [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100009598, updated on 14-Jun-2019

    Summary

    Gene symbol
    MMP14
    Gene description
    matrix metallopeptidase 14
    See related
    Ensembl:ENSOCUG00000010244
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Also known as
    MMP1
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs

    Genomic context

    See MMP14 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    102 current OryCun2.0 (GCF_000003625.3) 17 NC_013685.1 (43077378..43087282)

    Chromosome 17 - NC_013685.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 7 member 7 Neighboring gene mitochondrial ribosomal protein L52 Neighboring gene LDL receptor related protein 10 Neighboring gene RRAD and GEM like GTPase 2

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_013685.1 Chromosome 17 Reference OryCun2.0 Primary Assembly

    Pathways from BioSystems

    • GnRH signaling pathway, organism-specific biosystem (from KEGG)
      GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
    • GnRH signaling pathway, conserved biosystem (from KEGG)
      GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
    • TNF signaling pathway, organism-specific biosystem (from KEGG)
      TNF signaling pathway, organism-specific biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
    • TNF signaling pathway, conserved biosystem (from KEGG)
      TNF signaling pathway, conserved biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    matrix metalloproteinase-14; LOW QUALITY PROTEIN: matrix metalloproteinase-14
    Names
    MMP-14
    MT-MMP 1
    MT1-MMP
    MT1MMP
    MTMMP1
    matrix metallopeptidase 1 (interstitial collagenase)
    matrix metallopeptidase 14 (membrane-inserted)
    membane-type 1 metalloproteinase
    membrane type 1 metalloproteinase
    membrane-type matrix metalloproteinase 1
    membrane-type-1 matrix metalloproteinase
    NP_001076262.1
    XP_017203390.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082793.1NP_001076262.1  matrix metalloproteinase-14 precursor

      See identical proteins and their annotated locations for NP_001076262.1

      Status: PROVISIONAL

      Source sequence(s)
      U83918
      UniProtKB/Swiss-Prot
      Q95220
      Conserved Domains (5) summary
      cd00094
      Location:316508
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:118284
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:118284
      Peptidase_M10; Matrixin
      pfam01471
      Location:3688
      PG_binding_1; Putative peptidoglycan binding domain
      pfam11857
      Location:560582
      DUF3377; Domain of unknown function (DUF3377)

    RefSeqs of Annotated Genomes: Oryctolagus cuniculus Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference OryCun2.0 Primary Assembly

    Genomic

    1. NC_013685.1 Reference OryCun2.0 Primary Assembly

      Range
      43077378..43087282
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017347901.1XP_017203390.1  LOW QUALITY PROTEIN: matrix metalloproteinase-14 isoform X1

    Support Center