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    tdo2a tryptophan 2,3-dioxygenase a [ Danio rerio (zebrafish) ]

    Gene ID: 100008541, updated on 1-Aug-2018

    Summary

    Official Symbol
    tdo2aprovided by ZNC
    Official Full Name
    tryptophan 2,3-dioxygenase aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1187
    See related
    Ensembl:ENSDARG00000071429 Vega:OTTDARG00000028044
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
    Also known as
    tdo2; fb62b10; wu:fb62b10; zgc:103693

    Genomic context

    See tdo2a in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (36738074..36750584)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (36397760..36410270)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene nei-like DNA glycosylase 3 Neighboring gene si:dkey-237h12.3 Neighboring gene aspartylglucosaminidase Neighboring gene cathepsin O Neighboring gene ring finger protein 130

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC171678, MGC171685

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    heme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    tryptophan 2,3-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tryptophan 2,3-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    tryptophan 2,3-dioxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    protein homotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    tryptophan catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    tryptophan catabolic process to acetyl-CoA IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tryptophan catabolic process to kynurenine IEA
    Inferred from Electronic Annotation
    more info
     
    tryptophan catabolic process to kynurenine ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    tryptophan 2,3-dioxygenase A
    NP_001096086.1
    XP_021336628.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102616.2NP_001096086.1  tryptophan 2,3-dioxygenase A

      See identical proteins and their annotated locations for NP_001096086.1

      Status: PROVISIONAL

      Source sequence(s)
      BC150376
      UniProtKB/Swiss-Prot
      A7MBU6
      Related
      ENSDARP00000096367.4, OTTDARP00000023913, ENSDART00000105590.6, OTTDART00000029274
      Conserved Domains (1) summary
      pfam03301
      Location:25371
      Trp_dioxygenase; Tryptophan 2,3-dioxygenase

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      36738074..36750584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480953.1XP_021336628.1  tryptophan 2,3-dioxygenase A isoform X1

      Conserved Domains (1) summary
      pfam03301
      Location:1265
      Trp_dioxygenase; Tryptophan 2,3-dioxygenase

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394922.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      119067..131932
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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