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    ddr1 discoidin domain receptor tyrosine kinase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 100007346, updated on 9-Sep-2018

    Summary

    Official Symbol
    ddr1provided by ZNC
    Official Full Name
    discoidin domain receptor tyrosine kinase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060323-2
    See related
    Ensembl:ENSDARG00000078523
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
    Orthologs

    Genomic context

    See ddr1 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (21548224..21620895, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (21746573..21816649, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene serine/threonine-protein kinase 31-like Neighboring gene serine/threonine kinase 31 Neighboring gene si:ch211-154o6.2 Neighboring gene guanine nucleotide binding protein-like 1

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    collagen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine kinase collagen receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein tyrosine kinase collagen receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    epithelial discoidin domain-containing receptor 1
    Names
    discoidin domain receptor family, member 1
    XP_009290548.1
    XP_009290549.1
    XP_009290550.1
    XP_009290551.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      21548224..21620895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009292273.3XP_009290548.1  epithelial discoidin domain-containing receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_009290548.1

      UniProtKB/TrEMBL
      E7F3X9
      Related
      ENSDARP00000152067.1, ENSDART00000189460.1
      Conserved Domains (4) summary
      smart00219
      Location:668966
      TyrKc; Tyrosine kinase, catalytic domain
      smart00231
      Location:34189
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:37188
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl21453
      Location:662968
      PKc_like; Protein Kinases, catalytic domain
    2. XM_009292275.3XP_009290550.1  epithelial discoidin domain-containing receptor 1 isoform X2

      Related
      ENSDARP00000146875.1, ENSDART00000188856.1
      Conserved Domains (4) summary
      smart00219
      Location:652950
      TyrKc; Tyrosine kinase, catalytic domain
      smart00231
      Location:34189
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:37188
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl21453
      Location:646952
      PKc_like; Protein Kinases, catalytic domain
    3. XM_009292276.3XP_009290551.1  epithelial discoidin domain-containing receptor 1 isoform X3

      Conserved Domains (4) summary
      smart00219
      Location:630928
      TyrKc; Tyrosine kinase, catalytic domain
      smart00231
      Location:34189
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:37188
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl21453
      Location:624930
      PKc_like; Protein Kinases, catalytic domain
    4. XM_009292274.3XP_009290549.1  epithelial discoidin domain-containing receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_009290549.1

      UniProtKB/TrEMBL
      E7F3X9
      Conserved Domains (4) summary
      smart00219
      Location:668966
      TyrKc; Tyrosine kinase, catalytic domain
      smart00231
      Location:34189
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:37188
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl21453
      Location:662968
      PKc_like; Protein Kinases, catalytic domain
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