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TSL Protein kinase superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 832217, updated on 18-Sep-2024
Official Symbol
TSL
Official Full Name
Protein kinase superfamily protein
Primary source
TAIR:AT5G20930
Locus tag
AT5G20930
See related
Araport:AT5G20930
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F22D1.100; F22D1_100; PROTEIN KINASE TSL; TOUSLED
Summary
Nuclear serine/threonine protein kinase that requires a coiled-coil region for oligomerization and catalytic activity. Required for leaf and flower development. Expression localized to the developing style by stage 13.
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Location:
chromosome: 5
Exon count:
16
Sequence:
Chromosome: 5; NC_003076.8 (7097868..7103206)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene ncRNA Neighboring gene eukaryotic translation initiation factor 2 beta subunit Neighboring gene Glycosyl hydrolase family protein Neighboring gene ncRNA Neighboring gene DUF3148 family protein

Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The protein kinase TOUSLED facilitates RNAi in Arabidopsis. Uddin MN, et al. Nucleic Acids Res, 2014 Jul. PMID 24920830, Free PMC Article
  2. The protein kinase TOUSLED is required for maintenance of transcriptional gene silencing in Arabidopsis. Wang Y, et al. EMBO Rep, 2007 Jan. PMID 17110953, Free PMC Article
  3. TOUSLED is a nuclear serine/threonine protein kinase that requires a coiled-coil region for oligomerization and catalytic activity. Roe JL, et al. J Biol Chem, 1997 Feb 28. PMID 9038200
  4. The Tousled gene in A. thaliana encodes a protein kinase homolog that is required for leaf and flower development. Roe JL, et al. Cell, 1993 Dec 3. PMID 8252629
  5. TOUSLED kinase activity oscillates during the cell cycle and interacts with chromatin regulators. Ehsan H, et al. Plant Physiol, 2004 Apr. PMID 15047893, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

NM_122101.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of post-transcriptional gene silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 
Preferred Names
Protein kinase superfamily protein
NP_568405.1
  • TOUSLED (TSL); FUNCTIONS IN: protein serine/threonine kinase activity, kinase activity; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: nucleus, chloroplast, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: ataurora3 (TAIR:AT2G45490.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    7097868..7103206
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_122101.2 → NP_568405.1  Protein kinase superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_568405.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q39238, Q8LPL1
    UniProtKB/TrEMBL
    A0A178UBG5, A0A5S9Y610, A0A7G2FE35
    Conserved Domains (1) summary
    cd13990
    Location:408 → 682
    STKc_TLK; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q39238.1

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