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P5CR pyrroline-5- carboxylate (P5C) reductase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 831332, updated on 26-May-2022

Summary

Gene symbol
P5CR
Gene description
pyrroline-5- carboxylate (P5C) reductase
Primary source
Araport:AT5G14800
Locus tag
AT5G14800
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AT-P5C1; AT-P5R; EMB2772; EMBRYO DEFECTIVE 2772; pyrroline-5- carboxylate (P5C) reductase; PYRROLINE-5- CARBOXYLATE (P5C) REDUCTASE; T9L3.100; T9L3_100
Summary
Delta 1-pyrroline-5-carboxylate reductase, catalyzes the final step in proline biosynthesis from glutamate and ornithine.In situ hybridization indicated that under normal growth conditions, the highest concentration of P5CR transcripts occurs in the cortical parenchyma, phloem, vascular cambium and pith parenchyma in the vicinity of the protoxylem. Single gene in Arabidopsis.
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Genomic context

See P5CR in Genome Data Viewer
Location:
chromosome: 5
Exon count:
7
Sequence:
Chromosome: 5; NC_003076.8 (4785960..4787996, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene formate dehydrogenase Neighboring gene ARM repeat superfamily protein Neighboring gene hypothetical protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the P5CR gene: The P5CR gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, rice, and frog.
  • Orthologs
NM_001085115.1
NM_121484.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables pyrroline-5-carboxylate reductase activity IEA
Inferred from Electronic Annotation
more info
 
enables pyrroline-5-carboxylate reductase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables pyrroline-5-carboxylate reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in L-proline biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within proline biosynthetic process IDA
Inferred from Direct Assay
more info
 
involved_in proline biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to heat IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to salt stress IEP
Inferred from Expression Pattern
more info
PubMed 

General protein information

Preferred Names
pyrroline-5- carboxylate (P5C) reductase
NP_001078584.1
  • pyrroline-5- carboxylate (P5C) reductase (P5CR); CONTAINS InterPro DOMAIN/s: NADP oxidoreductase, coenzyme F420-dependent (InterPro:IPR004455), NAD(P)-binding domain (InterPro:IPR016040), Delta 1-pyrroline-5-carboxylate reductase (InterPro:IPR000304); Has 7429 Blast hits to 7426 proteins in 2378 species: Archae - 102; Bacteria - 5104; Metazoa - 368; Fungi - 229; Plants - 70; Viruses - 0; Other Eukaryotes - 1556 (source: NCBI BLink).
NP_196984.1
  • pyrroline-5- carboxylate (P5C) reductase (P5CR); FUNCTIONS IN: pyrroline-5-carboxylate reductase activity; INVOLVED IN: response to salt stress, response to heat, proline biosynthetic process; LOCATED IN: cell wall, cytoplasm; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: NADP oxidoreductase, coenzyme F420-dependent (InterPro:IPR004455), NAD(P)-binding domain (InterPro:IPR016040), Delta 1-pyrroline-5-carboxylate reductase (InterPro:IPR000304); Has 7885 Blast hits to 7882 proteins in 2434 species: Archae - 115; Bacteria - 5234; Metazoa - 373; Fungi - 241; Plants - 70; Viruses - 0; Other Eukaryotes - 1852 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    4785960..4787996 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_121484.5NP_196984.1  pyrroline-5- carboxylate (P5C) reductase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_196984.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P54904
    UniProtKB/TrEMBL
    A0A178UNE0
    Conserved Domains (1) summary
    PLN02688
    Location:11276
    PLN02688; pyrroline-5-carboxylate reductase
  2. NM_001085115.1NP_001078584.1  pyrroline-5- carboxylate (P5C) reductase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001078584.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4K884
    Conserved Domains (3) summary
    PLN02688
    Location:11215
    PLN02688; pyrroline-5-carboxylate reductase
    pfam03807
    Location:14107
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
    pfam14748
    Location:168215
    P5CR_dimer; Pyrroline-5-carboxylate reductase dimerization