STY46 ACT-like protein tyrosine kinase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: STY46
Gene description: ACT-like protein tyrosine kinase family protein
Primary source: Araport:AT4G38470
Locus tag: AT4G38470
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F20M13.30; F20M13_30; serine/threonine/tyrosine kinase 46
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Genomic context

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See STY46 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 15

Sequence:: Chromosome: 4; NC_003075.7 (17998896..18003757)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The ACT domain in chloroplast precursor-phosphorylating STY8, STY17, and STY46 kinases regulates activity and substrate binding.
Title: The ACT domain in chloroplast precursor-phosphorylating STY kinases binds metabolites and allosterically regulates kinase activity.
The protein kinase AT4G38470 could represent a subunit of a regulatory network involved in the cytosolic events of chloroplast protein import.
Title: A protein kinase family in Arabidopsis phosphorylates chloroplast precursor proteins.

Submit: New GeneRIF Correction

General gene information

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Homology

Orthologs

NM_001342498.1

Supported by ESTs:

NM_001342499.1

Supported by ESTs:

NM_120008.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine/tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine/tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to hypoxia	HEP more info	PubMed
acts_upstream_of_or_within chloroplast organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to abscisic acid	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: ACT-like protein tyrosine kinase family protein

NP_568041.1

ACT-like protein tyrosine kinase family protein; FUNCTIONS IN: protein serine/threonine/tyrosine kinase activity, protein kinase activity; INVOLVED IN: protein amino acid phosphorylation, metabolic process; LOCATED IN: cytosol; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Serine/threonine-protein kinase domain (InterPro:IPR002290), Amino acid-binding ACT (InterPro:IPR002912), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Serine/threonine protein kinase-like, ATMRK (InterPro:IPR015783), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: ACT-like protein tyrosine kinase family protein (TAIR:AT4G35780.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

17998896..18003757

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_120008.2 → NP_568041.1 ACT-like protein tyrosine kinase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_568041.1

Status: REVIEWED

UniProtKB/Swiss-Prot

F4JTP5, Q9SZM7

Conserved Domains (2) summary

cd13999
Location:296 → 539

STKc_MAP3K-like; Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine/Threonine kinases

cl09141
Location:176 → 241

ACT; ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme
NM_001342499.1 → NP_001328293.1 ACT-like protein tyrosine kinase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B481
NM_001342498.1 → NP_001328294.1 ACT-like protein tyrosine kinase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B466