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AT4G33150 lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme [ Arabidopsis thaliana (thale cress) ]

Gene ID: 829452, updated on 19-Aug-2022

Summary

Gene symbol
AT4G33150
Gene description
lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme
Primary source
Araport:AT4G33150
Locus tag
AT4G33150
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F4I10.80; F4I10_80; LKR; LKR/SDH; LYSINE-KETOGLUTARATE REDUCTASE/SACCHAROPINE DEHYDROGENASE; SACCHAROPINE DEHYDROGENASE; SDH
Summary
Encodes two proteins. One protein is the monofunctional saccharopine dehydrogenase involved in lysine degradation. The longer protein from the same LKR/SDH locus is bifunctional and also has saccharopine dehydrogenase activity. The monofunctional SDH functions mainly to enhance the flux of lysine catabolism. Gene expression is induced by abscisic acid, jasmonate, and under sucrose starvation.
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Genomic context

See AT4G33150 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
25
Sequence:
Chromosome: 4; NC_003075.7 (15985174..15991633, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Haloacid dehalogenase-like hydrolase (HAD) superfamily protein Neighboring gene hypothetical protein Neighboring gene F-box family protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Homology

  • Homologs of the AT4G33150 gene: The AT4G33150 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, S.pombe, M.oryzae, N.crassa, rice, and frog.
  • Orthologs
NM_001160811.2
NM_001342200.1
NM_119469.4
NM_179155.4

General protein information

Preferred Names
lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme
NP_001154283.1
  • lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme; CONTAINS InterPro DOMAIN/s: Saccharopine dehydrogenase / Homospermidine synthase (InterPro:IPR005097); Has 1125 Blast hits to 1121 proteins in 331 species: Archae - 40; Bacteria - 296; Metazoa - 110; Fungi - 190; Plants - 55; Viruses - 0; Other Eukaryotes - 434 (source: NCBI BLink).
NP_567914.1
  • lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme; CONTAINS InterPro DOMAIN/s: Alanine dehydrogenase/PNT, C-terminal (InterPro:IPR007698), Saccharopine dehydrogenase / Homospermidine synthase (InterPro:IPR005097), Alanine dehydrogenase/PNT, N-terminal (InterPro:IPR007886), LOR/SDH bifunctional enzyme, conserved domain (InterPro:IPR007545); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_849486.1
  • lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme; CONTAINS InterPro DOMAIN/s: Alanine dehydrogenase/PNT, C-terminal (InterPro:IPR007698), Saccharopine dehydrogenase / Homospermidine synthase (InterPro:IPR005097), Alanine dehydrogenase/PNT, N-terminal (InterPro:IPR007886), LOR/SDH bifunctional enzyme, conserved domain (InterPro:IPR007545); Has 1973 Blast hits to 1848 proteins in 422 species: Archae - 66; Bacteria - 527; Metazoa - 218; Fungi - 314; Plants - 71; Viruses - 0; Other Eukaryotes - 777 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    15985174..15991633 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_179155.4NP_849486.1  lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_849486.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654FV44, F4JVY8
    Conserved Domains (1) summary
    PLN02819
    Location:101064
    PLN02819; lysine-ketoglutarate reductase/saccharopine dehydrogenase
  2. NM_119469.4NP_567914.1  lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_567914.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654FV44, F4JVY8
    Conserved Domains (1) summary
    PLN02819
    Location:101064
    PLN02819; lysine-ketoglutarate reductase/saccharopine dehydrogenase
  3. NM_001342200.1NP_001328161.1  lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654FV44, F4JVY8
    Conserved Domains (1) summary
    PLN02819
    Location:101064
    PLN02819; lysine-ketoglutarate reductase/saccharopine dehydrogenase
  4. NM_001160811.2NP_001154283.1  lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001154283.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9SMZ4
    Conserved Domains (3) summary
    COG1748
    Location:7480
    Lys9; Saccharopine dehydrogenase, NADP-dependent [Amino acid transport and metabolism]
    pfam03435
    Location:7142
    Sacchrp_dh_NADP; Saccharopine dehydrogenase NADP binding domain
    pfam16653
    Location:146474
    Sacchrp_dh_C; Saccharopine dehydrogenase C-terminal domain