OPR3 oxophytodienoate-reductase 3 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: OPR3
Official Full Name: oxophytodienoate-reductase 3
Primary source: TAIR:AT2G06050
Locus tag: AT2G06050
See related: Araport:AT2G06050
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: 11-REDUCTASE; 12-OXO-PHYTODIENOATE REDUCTASE; 12-OXOPHYTODIENOATE-10; AtOPR3; DDE1; DELAYED DEHISCENCE 1; F5K7.19; F5K7_19; oxophytodienoate-reductase 3
Summary: Encodes a 12-oxophytodienoate reductase that is required for jasmonate biosynthesis. Mutants are male sterile and defective in pollen dehiscence. Shows activity towards 2,4,6-trinitrotoluene.
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Genomic context

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See OPR3 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 5

Sequence:: Chromosome: 2; NC_003071.7 (2359114..2362375, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

12-Oxophytodienoic Acid Reductase 3 (OPR3) Functions as NADPH-Dependent alpha,beta-Ketoalkene Reductase in Detoxification and Monodehydroascorbate Reductase in Redox Homeostasis.
Title: 12-Oxophytodienoic Acid Reductase 3 (OPR3) Functions as NADPH-Dependent α,β-Ketoalkene Reductase in Detoxification and Monodehydroascorbate Reductase in Redox Homeostasis.
The authors found that OPR3 specifically inhibited primary root growth under phosphate deficiency via suppressing root tip growth at the transcriptional level, revealing an important novel function of OPR3 in regulating primary root response to the nutrient stress.
Title: AtOPR3 specifically inhibits primary root growth in Arabidopsis under phosphate deficiency.
In structures of substrate-free and 8-iso-PGA1 bound AtOPR3, the two monomers observed in the asymmetric unit of AtOPR3 crystals can be superimposed with the corresponding protomers of the LeOPR3 dimer, suggesting a similar dimeric structure for AtOPR3.
Title: Crystal structure of Arabidopsis thaliana 12-oxophytodienoate reductase isoform 3 in complex with 8-iso prostaglandin A(1).
Over-expression of OPR3 does not strongly induce BPEp accumulation, but exogenous application of jasmonate restores BPEp expression in the opr3 mutant.
Title: Jasmonate controls late development stages of petal growth in Arabidopsis thaliana.
OPR3 was found to be induced by touch, wounding, methyl jasmonate, NaCl and CaCl(2) while ethylene and darkness had no effect.
Title: Use of differential display for the identification of touch-induced genes from an ethylene-insensitive Arabidopsis mutant and partial characterization of these genes.
brassinosteroid-responsive gene
Title: Molecular analysis of brassinosteroid action.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001084415.2

Supported by ESTs:

NM_126619.4

Supported by ESTs:

NM_201702.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables 12-oxophytodienoate reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables 12-oxophytodienoate reductase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables FMN binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within jasmonic acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to fungus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to ozone	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to wounding	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within stamen development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in peroxisome	HDA more info	PubMed

General protein information

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Preferred Names: oxophytodienoate-reductase 3

NP_001077884.1

oxophytodienoate-reductase 3 (OPR3); FUNCTIONS IN: 12-oxophytodienoate reductase activity; INVOLVED IN: response to jasmonic acid stimulus, response to fungus, jasmonic acid biosynthetic process, response to wounding, response to ozone; LOCATED IN: peroxisome; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: NADH:flavin oxidoreductase/NADH oxidase, N-terminal (InterPro:IPR001155), Aldolase-type TIM barrel (InterPro:IPR013785); BEST Arabidopsis thaliana protein match is: 12-oxophytodienoate reductase 2 (TAIR:AT1G76690.1); Has 13056 Blast hits to 13024 proteins in 2039 species: Archae - 127; Bacteria - 9671; Metazoa - 31; Fungi - 870; Plants - 454; Viruses - 0; Other Eukaryotes - 1903 (source: NCBI BLink).

NP_178662.1

oxophytodienoate-reductase 3 (OPR3); FUNCTIONS IN: 12-oxophytodienoate reductase activity; INVOLVED IN: response to jasmonic acid stimulus, response to fungus, jasmonic acid biosynthetic process, response to wounding, response to ozone; LOCATED IN: peroxisome; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), NADH:flavin oxidoreductase/NADH oxidase, N-terminal (InterPro:IPR001155); BEST Arabidopsis thaliana protein match is: 12-oxophytodienoate reductase 2 (TAIR:AT1G76690.1); Has 13056 Blast hits to 13024 proteins in 2039 species: Archae - 127; Bacteria - 9671; Metazoa - 31; Fungi - 870; Plants - 454; Viruses - 0; Other Eukaryotes - 1903 (source: NCBI BLink).

NP_973431.1

oxophytodienoate-reductase 3 (OPR3); FUNCTIONS IN: 12-oxophytodienoate reductase activity; INVOLVED IN: response to jasmonic acid stimulus, response to fungus, jasmonic acid biosynthetic process, response to wounding, response to ozone; LOCATED IN: peroxisome; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), NADH:flavin oxidoreductase/NADH oxidase, N-terminal (InterPro:IPR001155); BEST Arabidopsis thaliana protein match is: 12-oxophytodienoate reductase 2 (TAIR:AT1G76690.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).