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FZL FZO-like protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 839566, updated on 18-Sep-2024
Official Symbol
FZL
Official Full Name
FZO-like protein
Primary source
TAIR:AT1G03160
Locus tag
AT1G03160
See related
Araport:AT1G03160
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F10O3.1; F10O3_1; FZO-like
Summary
A new plant-specific member of the dynamin superfamily; defines a new protein class within the dynamin superfamily of membrane remodeling GTPases that regulates organization of the thylakoid network in plants. Targeted to chloroplasts and associated with thylakoid and envelope membranes as punctate structures. Knockout mutants have abnormalities in chloroplast and thylakoid morphology, including disorganized grana stacks and alterations in the relative proportions of grana and stroma thylakoids. Overexpression of FZL-GFP also conferred defects in thylakoid organization.
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See FZL in Genome Data Viewer
Location:
chromosome: 1
Exon count:
11
Sequence:
Chromosome: 1; NC_003070.9 (761261..766194)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Acyl-CoA N-acyltransferases (NAT) superfamily protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene FANTASTIC four-like protein (DUF3049)

Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A Role of the FUZZY ONIONS LIKE Gene in Regulating Cell Death and Defense in Arabidopsis. Tremblay A, et al. Sci Rep, 2016 Nov 29. PMID 27898102, Free PMC Article
  2. A mutation in the FZL gene of Arabidopsis causing alteration in chloroplast morphology results in a lesion mimic phenotype. Landoni M, et al. J Exp Bot, 2013 Nov. PMID 23963675, Free PMC Article
  3. FZL, an FZO-like protein in plants, is a determinant of thylakoid and chloroplast morphology. Gao H, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16617119, Free PMC Article
  4. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article
  5. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these data suggest that the Arabidopsis FZL gene is a negative regulator of cell death and disease resistance, possibly through regulating reactive oxygen species and autophagy pathways in the chloroplast.
    Title: A Role of the FUZZY ONIONS LIKE Gene in Regulating Cell Death and Defense in Arabidopsis.
  2. The characterization of an Arabidopsis lesion mimic mutant lacking the function of the FZL gene is reported.
    Title: A mutation in the FZL gene of Arabidopsis causing alteration in chloroplast morphology results in a lesion mimic phenotype.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description
NM_001083983.1
NM_001331388.1
NM_001331389.1
NM_100198.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of plant-type hypersensitive response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within thylakoid membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within vegetative to reproductive phase transition of meristem IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
FZO-like protein
NP_001077452.1
  • FZO-like (FZL); FUNCTIONS IN: thiamin-phosphate diphosphorylase activity, GTP binding, GTPase activity; INVOLVED IN: vegetative to reproductive phase transition of meristem, thylakoid membrane organization; LOCATED IN: chloroplast membrane, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thiamine monophosphate synthase (InterPro:IPR003733), Protein synthesis factor, GTP-binding (InterPro:IPR000795); Has 4303 Blast hits to 3755 proteins in 1119 species: Archae - 53; Bacteria - 3491; Metazoa - 428; Fungi - 84; Plants - 61; Viruses - 0; Other Eukaryotes - 186 (source: NCBI BLink).
NP_171815.3
  • FZO-like (FZL); FUNCTIONS IN: thiamin-phosphate diphosphorylase activity, GTP binding; INVOLVED IN: vegetative to reproductive phase transition of meristem, thylakoid membrane organization; LOCATED IN: chloroplast membrane, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thiamine monophosphate synthase (InterPro:IPR003733), GTP-binding protein, HSR1-related (InterPro:IPR002917); Has 4318 Blast hits to 3768 proteins in 1124 species: Archae - 53; Bacteria - 3501; Metazoa - 428; Fungi - 84; Plants - 66; Viruses - 0; Other Eukaryotes - 186 (source: NCBI BLink).

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    761261..766194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_100198.5 → NP_171815.3  FZO-like protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_171815.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q1KPV0, Q67Z21, Q6NQ84, Q9SA53, Q9ZVR8
    UniProtKB/TrEMBL
    A0A654E8G4, A0A7G2DRH1
    Conserved Domains (2) summary
    cd09912
    Location:350 → 566
    DLP_2; Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins
    cl21457
    Location:96 → 212
    TIM; TIM-like beta/alpha barrel domains

  2. NM_001331388.1 → NP_001322638.1  FZO-like protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AUL2

  3. NM_001331389.1 → NP_001322639.1  FZO-like protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AUL4, A0A7G2DRH1

  4. NM_001083983.1 → NP_001077452.1  FZO-like protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001077452.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q1KPV0
    Conserved Domains (2) summary
    cd09912
    Location:350 → 566
    DLP_2; Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins
    cl21457
    Location:96 → 212
    TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1KPV0.1

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