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    Rfx2 regulatory factor X, 2 (influences HLA class II expression) [ Mus musculus (house mouse) ]

    Gene ID: 19725, updated on 31-Jan-2019

    Summary

    Official Symbol
    Rfx2provided by MGI
    Official Full Name
    regulatory factor X, 2 (influences HLA class II expression)provided by MGI
    Primary source
    MGI:MGI:106583
    See related
    Ensembl:ENSMUSG00000024206
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5430432H19Rik
    Expression
    Biased expression in testis adult (RPKM 137.0), ovary adult (RPKM 9.7) and 4 other tissues See more
    Orthologs

    Genomic context

    See Rfx2 in Genome Data Viewer
    Location:
    17 D; 17 29.5 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (56775897..56831008, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (56915320..56970431, complement)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene dihydrouridine synthase 3-like (S. cerevisiae) Neighboring gene proline rich 22 Neighboring gene predicted gene, 41604 Neighboring gene acyl-CoA synthetase bubblegum family member 2 Neighboring gene RIKEN cDNA 1700061G19 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acrosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA-binding protein RFX2
    Names
    regulatory factor X 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009056.2NP_033082.1  DNA-binding protein RFX2 isoform 2

      See identical proteins and their annotated locations for NP_033082.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK044439, CT010491
      Consensus CDS
      CCDS28915.1
      UniProtKB/Swiss-Prot
      P48379
      Related
      ENSMUSP00000084010.5, ENSMUST00000086801.6
      Conserved Domains (2) summary
      pfam02257
      Location:166242
      RFX_DNA_binding; RFX DNA-binding domain
      pfam04589
      Location:19148
      RFX1_trans_act; RFX1 transcription activation region
    2. NM_027787.1NP_082063.1  DNA-binding protein RFX2 isoform 1

      See identical proteins and their annotated locations for NP_082063.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK044439, CT010491
      Consensus CDS
      CCDS50156.1
      UniProtKB/Swiss-Prot
      P48379
      Related
      ENSMUSP00000002444.7, ENSMUST00000002444.14
      Conserved Domains (2) summary
      pfam02257
      Location:195267
      RFX_DNA_binding; RFX DNA-binding domain
      pfam04589
      Location:19148
      RFX1_trans_act; RFX1 transcription activation region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      56775897..56831008 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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