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    pyd1 dihydropyrimidine dehydrogenase [ Dictyostelium discoideum AX4 ]

    Gene ID: 8616259, updated on 18-Apr-2019

    Summary

    Gene symbol
    pyd1
    Gene description
    dihydropyrimidine dehydrogenase
    Primary source
    dictyBase:DDB_G0267966
    Locus tag
    DDB_G0267966
    Gene type
    protein coding
    RNA name
    dihydropyrimidine dehydrogenase
    RefSeq status
    PROVISIONAL
    Organism
    Dictyostelium discoideum AX4 (strain: AX4)
    Lineage
    Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium
    Old locus tag
    DDBDRAFT_0189681; DDBDRAFT_0231100; DDB_0189681; DDB_0231100

    Genomic context

    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_007087.3 (1202711..1205883)

    Chromosome 1 - NC_007087.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene spore coat protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    NADP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    dihydropyrimidine dehydrogenase (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dihydropyrimidine dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
     
    dihydropyrimidine dehydrogenase (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    iron-sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
     
    uracil binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    beta-alanine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    thymidine catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    thymine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    uracil catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    uracil catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_007087.3 Reference assembly

      Range
      1202711..1205883
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_642360.1XP_647452.1  dihydropyrimidine dehydrogenase [Dictyostelium discoideum AX4]

      See identical proteins and their annotated locations for XP_647452.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q55FT1
      Conserved Domains (6) summary
      PRK08318
      Location:530997
      PRK08318; dihydropyrimidine dehydrogenase subunit B; Validated
      PRK11749
      Location:53506
      PRK11749; dihydropyrimidine dehydrogenase subunit A; Provisional
      cd02940
      Location:530832
      DHPD_FMN; Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and ...
      pfam13187
      Location:941985
      Fer4_9; 4Fe-4S dicluster domain
      pfam13450
      Location:192237
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      pfam14691
      Location:55167
      Fer4_20; Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
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