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    Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85496, updated on 18-Apr-2019

    Summary

    Official Symbol
    Enpp1provided by RGD
    Official Full Name
    ectonucleotide pyrophosphatase/phosphodiesterase 1provided by RGD
    Primary source
    RGD:628825
    See related
    Ensembl:ENSRNOG00000013994
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pc1; Npps
    Summary
    mutation of the human homolog is detected in patients with idiopathic infantile arterial calcification [RGD, Feb 2006]
    Expression
    Biased expression in Kidney (RPKM 90.9), Liver (RPKM 89.9) and 9 other tissues See more
    Orthologs

    Genomic context

    See Enpp1 in Genome Data Viewer
    Location:
    1p12
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (21748201..21813205)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (23228262..23292896)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 3 Neighboring gene uncharacterized LOC102553363 Neighboring gene uncharacterized LOC108349248 Neighboring gene uncharacterized LOC103690930 Neighboring gene cellular communication network factor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    NADH pyrophosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    insulin receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    insulin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoside-triphosphate diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoside-triphosphate diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleoside-triphosphate diphosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleotide diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleotide diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleotide diphosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphodiesterase I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphodiesterase I activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphodiesterase I activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphodiesterase I activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phosphodiesterase I activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    polysaccharide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    3'-phosphoadenosine 5'-phosphosulfate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    3'-phosphoadenosine 5'-phosphosulfate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ATP metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ATP metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    biomineral tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    bone remodeling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular phosphate ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    cellular phosphate ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to acidic pH IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to cAMP IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to transforming growth factor beta stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cerebellum development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cerebral cortex development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    generation of precursor metabolites and energy IEA
    Inferred from Electronic Annotation
    more info
     
    generation of precursor metabolites and energy ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    hippocampus development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    inorganic diphosphate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    inorganic diphosphate transport IEA
    Inferred from Electronic Annotation
    more info
     
    inorganic diphosphate transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    liver development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    melanocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    melanocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of bone mineralization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of fat cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of glucose import IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of hh target transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of ossification ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleic acid phosphodiester bond hydrolysis IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid phosphodiester bond hydrolysis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleoside triphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoside triphosphate catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoside triphosphate catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    olfactory bulb development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    phosphate-containing compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of bone mineralization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    sequestering of triglyceride IEA
    Inferred from Electronic Annotation
    more info
     
    sequestering of triglyceride ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    striatum development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    apical dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basal dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    integral component of membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    integral component of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ectonucleotide pyrophosphatase/phosphodiesterase family member 1
    Names
    E-NPP 1
    phosphodiesterase I/nucleotide pyrophosphatase 1
    plasma-cell membrane glycoprotein PC-1
    NP_445987.1
    XP_006227754.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053535.1NP_445987.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 1

      See identical proteins and their annotated locations for NP_445987.1

      Status: PROVISIONAL

      Source sequence(s)
      AF340186
      UniProtKB/Swiss-Prot
      Q924C3
      Related
      ENSRNOP00000019519.5, ENSRNOT00000019519.6
      Conserved Domains (4) summary
      smart00201
      Location:86126
      SO; Somatomedin B -like domains
      smart00477
      Location:657888
      NUC; DNA/RNA non-specific endonuclease
      pfam01663
      Location:194520
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:192560
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      21748201..21813205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006227692.3XP_006227754.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1

      Conserved Domains (4) summary
      smart00201
      Location:86126
      SO; Somatomedin B -like domains
      smart00477
      Location:656887
      NUC; DNA/RNA non-specific endonuclease
      pfam01663
      Location:194520
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:192560
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      19451097..19514516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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