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    Smad9 SMAD family member 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85435, updated on 2-Oct-2018

    Summary

    Official Symbol
    Smad9provided by RGD
    Official Full Name
    SMAD family member 9provided by RGD
    Primary source
    RGD:71004
    See related
    Ensembl:ENSRNOG00000058416
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Madh9; Smad8
    Summary
    transcriptional activator; acts as an intracellular mediator of transforming growth factor beta superfamily signalling [RGD, Feb 2006]
    Expression
    Biased expression in Lung (RPKM 33.8), Adrenal (RPKM 23.2) and 6 other tissues See more
    Orthologs

    Genomic context

    See Smad9 in Genome Data Viewer
    Location:
    2q26
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (143951725..144002025)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (163609377..163629230)

    Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene SPT20 homolog, SAGA complex component Neighboring gene exosome component 8 Neighboring gene ALG5, dolichyl-phosphate beta-glucosyltransferase Neighboring gene regulatory factor X-associated protein Neighboring gene 60S ribosomal protein L39 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Mullerian duct regression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    bone development ISO
    Inferred from Sequence Orthology
    more info
     
    cartilage development ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    hindbrain development ISO
    Inferred from Sequence Orthology
    more info
     
    midbrain development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    ureteric bud development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    mothers against decapentaplegic homolog 9
    Names
    MAD homolog 9
    SMAD 9
    mothers against DPP homolog 9

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138872.1NP_620227.1  mothers against decapentaplegic homolog 9

      See identical proteins and their annotated locations for NP_620227.1

      Status: PROVISIONAL

      Source sequence(s)
      AF012347
      UniProtKB/Swiss-Prot
      O54835
      Conserved Domains (2) summary
      cd10490
      Location:13136
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cl00056
      Location:230434
      MH2; C-terminal Mad Homology 2 (MH2) domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

      Range
      143951725..144002025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591145.1XP_017446634.1  mothers against decapentaplegic homolog 9 isoform X1

      UniProtKB/TrEMBL
      G3V603
      Related
      ENSRNOP00000070480.1, ENSRNOT00000079544.1
      Conserved Domains (2) summary
      cd10490
      Location:13136
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cl00056
      Location:230430
      MH2; C-terminal Mad Homology 2 (MH2) domain
    2. XM_017591146.1XP_017446635.1  mothers against decapentaplegic homolog 9 isoform X1

      UniProtKB/TrEMBL
      G3V603
      Conserved Domains (2) summary
      cd10490
      Location:13136
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cl00056
      Location:230430
      MH2; C-terminal Mad Homology 2 (MH2) domain

    Alternate Rn_Celera

    Genomic

    1. AC_000070.1 Alternate Rn_Celera

      Range
      133441288..133491482
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595808.1XP_017451297.1  mothers against decapentaplegic homolog 9 isoform X2

      UniProtKB/TrEMBL
      G3V603
      Conserved Domains (2) summary
      cd10490
      Location:13136
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cl00056
      Location:230430
      MH2; C-terminal Mad Homology 2 (MH2) domain
    2. XM_017595809.1XP_017451298.1  mothers against decapentaplegic homolog 9 isoform X2

      UniProtKB/TrEMBL
      G3V603
      Conserved Domains (2) summary
      cd10490
      Location:13136
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cl00056
      Location:230430
      MH2; C-terminal Mad Homology 2 (MH2) domain
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