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    Ackr3 atypical chemokine receptor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84348, updated on 18-Apr-2019

    Summary

    Official Symbol
    Ackr3provided by RGD
    Official Full Name
    atypical chemokine receptor 3provided by RGD
    Primary source
    RGD:620601
    See related
    Ensembl:ENSRNOG00000019622
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rdc1; Cxcr7; Cmkor1
    Summary
    human homolog is an orphan G-protein coupled receptor and may be associated with lipomas [RGD, Feb 2006]
    Expression
    Biased expression in Heart (RPKM 129.4), Lung (RPKM 118.2) and 9 other tissues See more
    Orthologs

    Genomic context

    See Ackr3 in Genome Data Viewer
    Location:
    9q36
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (97355881..97367455)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 9 NC_005108.3 (97046816..97058382)

    Chromosome 9 - NC_005108.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554789 Neighboring gene IQ motif containing with AAA domain 1 Neighboring gene uncharacterized LOC108351973 Neighboring gene uncharacterized LOC102555030 Neighboring gene uncharacterized LOC103690570

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    C-X-C chemokine binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    C-X-C chemokine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    C-X-C chemokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    C-X-C chemokine receptor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    coreceptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    scavenger receptor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    scavenger receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chemokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    chemokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of mesenchymal stem cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    receptor internalization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    vasculogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell surface ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    clathrin-coated pit ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    endosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    recycling endosome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    atypical chemokine receptor 3
    Names
    C-X-C chemokine receptor type 7
    CXC-R7
    CXCR-7
    G-protein coupled receptor RDC1 homolog
    RDC-1
    chemokine (C-X-C motif) receptor 7
    chemokine orphan receptor 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053352.1NP_445804.1  atypical chemokine receptor 3

      See identical proteins and their annotated locations for NP_445804.1

      Status: PROVISIONAL

      Source sequence(s)
      AF118816
      UniProtKB/Swiss-Prot
      O89039
      Related
      ENSRNOP00000026558.2, ENSRNOT00000026558.3
      Conserved Domains (1) summary
      pfam00001
      Location:62315
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005108.4 Reference Rnor_6.0 Primary Assembly

      Range
      97355881..97367455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245479.3XP_006245541.1  atypical chemokine receptor 3 isoform X1

      See identical proteins and their annotated locations for XP_006245541.1

      UniProtKB/Swiss-Prot
      O89039
      Conserved Domains (1) summary
      pfam00001
      Location:62315
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    Alternate Rn_Celera

    Genomic

    1. AC_000077.1 Alternate Rn_Celera

      Range
      88347205..88358728
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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