Format

Send to:

Choose Destination
    • Showing Current items.

    Pias3 protein inhibitor of activated STAT, 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83614, updated on 2-Oct-2018

    Summary

    Official Symbol
    Pias3provided by RGD
    Official Full Name
    protein inhibitor of activated STAT, 3provided by RGD
    Primary source
    RGD:708413
    See related
    Ensembl:ENSRNOG00000021218
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    voltage-gated K+ channel binding protein; involved in modulating the expression of Kv2 channels [RGD, Feb 2006]
    Expression
    Biased expression in Lung (RPKM 39.4), Adrenal (RPKM 32.8) and 9 other tissues See more
    Orthologs

    Genomic context

    See Pias3 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (198821377..198831533)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (218309595..218318467)

    Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene integrin subunit alpha 10 Neighboring gene ankyrin repeat domain 35 Neighboring gene nudix hydrolase 17 Neighboring gene RNA polymerase III subunit C

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    SUMO transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    SUMO transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    potassium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein C-terminus binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein N-terminus binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    TNFSF11-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    TNFSF11-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of osteoclast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein sumoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein sumoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 SUMO-protein ligase PIAS3
    Names
    E3 SUMO-protein transferase PIAS3
    KChAP
    potassium channel regulatory protein KChAP
    potassium channel-associated protein
    protein inhibitor of activated STAT protein 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031784.2NP_113972.2  E3 SUMO-protein ligase PIAS3

      See identical proteins and their annotated locations for NP_113972.2

      Status: PROVISIONAL

      Source sequence(s)
      AF032872
      UniProtKB/Swiss-Prot
      O70260
      Related
      ENSRNOP00000028814.3, ENSRNOT00000028814.5
      Conserved Domains (3) summary
      smart00513
      Location:1136
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:323371
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:126263
      PINIT; PINIT domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

      Range
      198821377..198831533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232992.3XP_006233054.1  E3 SUMO-protein ligase PIAS3 isoform X2

      See identical proteins and their annotated locations for XP_006233054.1

      Conserved Domains (3) summary
      smart00513
      Location:227
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:314362
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:117254
      PINIT; PINIT domain
    2. XM_006232993.3XP_006233055.1  E3 SUMO-protein ligase PIAS3 isoform X2

      See identical proteins and their annotated locations for XP_006233055.1

      Conserved Domains (3) summary
      smart00513
      Location:227
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:314362
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:117254
      PINIT; PINIT domain
    3. XM_006232991.3XP_006233053.1  E3 SUMO-protein ligase PIAS3 isoform X1

      Conserved Domains (3) summary
      smart00513
      Location:2853
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:340388
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:143280
      PINIT; PINIT domain
    4. XM_008761338.2XP_008759560.1  E3 SUMO-protein ligase PIAS3 isoform X3

      Conserved Domains (3) summary
      smart00513
      Location:2853
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:340388
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:143280
      PINIT; PINIT domain

    Alternate Rn_Celera

    Genomic

    1. AC_000070.1 Alternate Rn_Celera

      Range
      176757800..176765964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center