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    MKK2 MAP kinase kinase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829103, updated on 18-Apr-2019

    Summary

    Gene symbol
    MKK2
    Gene description
    MAP kinase kinase 2
    Primary source
    Araport:AT4G29810
    Locus tag
    AT4G29810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMKK2; F27B13.50; F27B13_50; MAP KINASE KINASE 1; MAP kinase kinase 2; MK1
    Summary
    encodes a MAP kinase kinase 2 that regulates MPK6 and MPK4 in response to cold and salt stresses. Co-expression with MEKK1 in protoplasts activated MKK2 activity, suggesting that MEKK1 may be a regulator of MKK2.

    Genomic context

    See MKK2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    8
    Sequence:
    Chromosome: 4; NC_003075.7 (14592963..14595384, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene serine/arginine repetitive matrix protein Neighboring gene PATATIN-like protein 8 Neighboring gene homolog of CFIM-25 Neighboring gene ncRNA Neighboring gene Transducin/WD40 repeat-like superfamily protein

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    • Homologs of the MKK2 gene: The MKK2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, M.oryzae, N.crassa, rice, and frog.
    • Orthologs
    NM_001036674.2
    NM_001125607.1
    NM_119127.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    MAP kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    MAP kinase kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    MAP kinase kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    MAPK cascade IC
    Inferred by Curator
    more info
    PubMed 
    MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    activation of MAPK activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    auxin transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cold acclimation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cold acclimation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response, incompatible interaction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    response to cold IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to cold IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to salt stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to salt stress IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    xylem and phloem pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    MAP kinase kinase 2
    NP_001031751.1
    • MAP kinase kinase 2 (MKK2); FUNCTIONS IN: MAP kinase kinase activity, kinase activity; INVOLVED IN: cold acclimation, MAPKKK cascade, response to salt stress, response to cold, defense response, incompatible interaction; LOCATED IN: plasma membrane, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: MAP kinase/ ERK kinase 1 (TAIR:AT4G26070.3); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001119079.1
    • MAP kinase kinase 2 (MKK2); FUNCTIONS IN: MAP kinase kinase activity, kinase activity; INVOLVED IN: cold acclimation, MAPKKK cascade, response to salt stress, response to cold, defense response, incompatible interaction; LOCATED IN: plasma membrane, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: MAP kinase/ ERK kinase 1 (TAIR:AT4G26070.3); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_194710.1
    • MAP kinase kinase 2 (MKK2); FUNCTIONS IN: MAP kinase kinase activity, kinase activity; INVOLVED IN: cold acclimation, MAPKKK cascade, response to salt stress, response to cold, defense response, incompatible interaction; LOCATED IN: plasma membrane, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase-like domain (InterPro:IPR011009), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: MAP kinase/ ERK kinase 1 (TAIR:AT4G26070.3); Has 131554 Blast hits to 129384 proteins in 4297 species: Archae - 179; Bacteria - 15130; Metazoa - 48544; Fungi - 12993; Plants - 32706; Viruses - 527; Other Eukaryotes - 21475 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      14592963..14595384 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119127.4NP_194710.1  MAP kinase kinase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194710.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9S7U9
      Conserved Domains (2) summary
      smart00220
      Location:71330
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06605
      Location:68335
      PKc_MAPKK; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein Kinase Kinase
    2. NM_001036674.2NP_001031751.1  MAP kinase kinase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031751.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9S7U9
      Conserved Domains (2) summary
      smart00220
      Location:80339
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06605
      Location:77344
      PKc_MAPKK; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein Kinase Kinase
    3. NM_001125607.1NP_001119079.1  MAP kinase kinase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001119079.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3H757
      Conserved Domains (2) summary
      smart00220
      Location:80334
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06605
      Location:77334
      PKc_MAPKK; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein Kinase Kinase
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