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    Gna12 G protein subunit alpha 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81663, updated on 18-Apr-2019

    Summary

    Official Symbol
    Gna12provided by RGD
    Official Full Name
    G protein subunit alpha 12provided by RGD
    Primary source
    RGD:71018
    See related
    Ensembl:ENSRNOG00000001235
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    may play a role in D5 dopamine receptor signal transduction and renal sodium transport [RGD, Feb 2006]
    Expression
    Biased expression in Kidney (RPKM 377.5), Heart (RPKM 344.9) and 9 other tissues See more
    Orthologs

    Genomic context

    See Gna12 in Genome Data Viewer
    Location:
    12q11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (15890202..15971212)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 12 NC_005111.3 (17889996..17970852)

    Chromosome 12 - NC_005111.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547234 Neighboring gene caspase recruitment domain family, member 11 Neighboring gene archaelysin family metallopeptidase 1 Neighboring gene BRCA1-associated ATM activator 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    D5 dopamine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    D5 dopamine receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    G-protein beta/gamma-subunit complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    dopamine receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    embryonic digit morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic digit morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of TOR signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of fibroblast migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    brush border membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    brush border membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    heterotrimeric G-protein complex TAS
    Traceable Author Statement
    more info
    PubMed 
    lateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    guanine nucleotide-binding protein subunit alpha-12
    Names
    g alpha-12
    guanine nucleotide binding protein (G protein) alpha 12
    guanine nucleotide binding protein, alpha 12

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031034.2NP_112296.1  guanine nucleotide-binding protein subunit alpha-12

      See identical proteins and their annotated locations for NP_112296.1

      Status: VALIDATED

      Source sequence(s)
      AABR07035471, AC119536
      UniProtKB/Swiss-Prot
      Q63210
      UniProtKB/TrEMBL
      Q45QM2
      Related
      ENSRNOP00000001654.5, ENSRNOT00000001654.7
      Conserved Domains (2) summary
      cd00066
      Location:56373
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
      smart00275
      Location:40377
      G_alpha; G protein alpha subunit

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005111.4 Reference Rnor_6.0 Primary Assembly

      Range
      15890202..15971212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000080.1 Alternate Rn_Celera

      Range
      15567135..15646904
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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