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    Atf2 activating transcription factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81647, updated on 19-Apr-2019

    Summary

    Official Symbol
    Atf2provided by RGD
    Official Full Name
    activating transcription factor 2provided by RGD
    Primary source
    RGD:621862
    See related
    Ensembl:ENSRNOG00000001597
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    transactivates tyrosine hydroxylase transcription; may be involved in regulation of catecholamine synthesis during neural development [RGD, Feb 2006]
    Expression
    Biased expression in Brain (RPKM 253.5), Thymus (RPKM 196.3) and 9 other tissues See more
    Orthologs

    Genomic context

    See Atf2 in Genome Data Viewer
    Location:
    3q23
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (60721137..60795951, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (67199880..67274694, complement)

    Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552328 Neighboring gene chimerin 1 Neighboring gene ubiquitin-conjugating enzyme E2 S-like Neighboring gene 60S ribosomal protein L19 pseudogene Neighboring gene ATP synthase membrane subunit c locus 3 Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    RNA polymerase II activating transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II activating transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    RNA polymerase II distal enhancer sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II distal enhancer sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    RNA polymerase II regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cAMP response element binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cAMP response element binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cAMP response element binding protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    cAMP response element binding protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enhancer sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    adipose tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    adipose tissue development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    amelogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to DNA damage stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    histone acetylation IEA
    Inferred from Electronic Annotation
    more info
     
    intra-S DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    intra-S DNA damage checkpoint ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    outflow tract morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    outflow tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cardiac muscle myoblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cardiac muscle myoblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of mitochondrial membrane permeability involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of mitochondrial membrane permeability involved in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of transforming growth factor beta2 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transforming growth factor beta2 production ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to osmotic stress ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to osmotic stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    site of double-strand break ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    cyclic AMP-dependent transcription factor ATF-2
    Names
    cAMP response element-binding protein CRE-BP1
    cAMP-dependent transcription factor ATF-2
    NP_112280.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031018.1NP_112280.1  cyclic AMP-dependent transcription factor ATF-2

      See identical proteins and their annotated locations for NP_112280.1

      Status: PROVISIONAL

      Source sequence(s)
      U38938
      UniProtKB/Swiss-Prot
      Q00969
      Related
      ENSRNOP00000002174.5, ENSRNOT00000002174.7
      Conserved Domains (3) summary
      cd12192
      Location:4784
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      cd14687
      Location:336396
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
      sd00019
      Location:931
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

      Range
      60721137..60795951 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000071.1 Alternate Rn_Celera

      Range
      58247269..58321865 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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