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    CYB5B cytochrome b5 type B [ Homo sapiens (human) ]

    Gene ID: 80777, updated on 13-Feb-2019


    Official Symbol
    CYB5Bprovided by HGNC
    Official Full Name
    cytochrome b5 type Bprovided by HGNC
    Primary source
    See related
    Ensembl:ENSG00000103018 MIM:611964
    Gene type
    protein coding
    RefSeq status
    Homo sapiens
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OMB5; CYB5-M; CYPB5M
    Ubiquitous expression in adrenal (RPKM 70.4), colon (RPKM 17.6) and 22 other tissues See more

    Genomic context

    See CYB5B in Genome Data Viewer
    Exon count:
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (69424595..69466264)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (69458498..69500167)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene transmembrane p24 trafficking protein 6 Neighboring gene telomeric repeat binding factor 2 Neighboring gene transmembrane protein 111 pseudogene Neighboring gene uncharacterized LOC105371325 Neighboring gene microRNA 1538

    Genomic regions, transcripts, and products


    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018


    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?


    NHGRI GWAS Catalog

    Gene-Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study.
    NHGRI GWA Catalog
    Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef The yeast two-hybrid screen and the coimmunoprecipitation analysis identify the HIV-1 Nef interacting human protein cytochrome b5 type B (CYB5B) in cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Biological oxidations, organism-specific biosystem (from REACTOME)
      Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Oxidation by Cytochrome P450, organism-specific biosystem (from WikiPathways)
      Oxidation by Cytochrome P450, organism-specific biosystemOxidation of a substrate by Cytochrome P450. Adapted from Niesink et al., Chapter 3, p. 47-48.
    • Phase 1 - Functionalization of compounds, organism-specific biosystem (from REACTOME)
      Phase 1 - Functionalization of compounds, organism-specific biosystemPhase 1 of metabolism is concerned with functionalization, that is the introduction or exposure of functional groups on the chemical structure of a compound. This provides a 'handle' for phase 2 conj...


    Products Interactant Other Gene Complex Source Pubs Description

    General gene information



    Clone Names

    • DKFZp686M0619

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    heme binding IDA
    Inferred from Direct Assay
    more info
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    protein binding IPI
    Inferred from Physical Interaction
    more info
    Process Evidence Code Pubs
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
    xenobiotic metabolic process TAS
    Traceable Author Statement
    more info
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
    membrane HDA PubMed 
    mitochondrial outer membrane TAS
    Traceable Author Statement
    more info

    General protein information

    Preferred Names
    cytochrome b5 type B
    cytochrome b5 outer mitochondrial membrane isoform
    cytochrome b5 type B (outer mitochondrial membrane)
    outer mitochondrial membrane cytochrome b5
    type 2 cyt-b5

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030579.2NP_085056.2  cytochrome b5 type B

      See identical proteins and their annotated locations for NP_085056.2

      Status: VALIDATED

      Source sequence(s)
      AC009032, AC026464, BC014431
      Consensus CDS
      ENSP00000308430.8, ENST00000307892.12
      Conserved Domains (2) summary
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly


    1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

      GenBank, FASTA, Sequence Viewer (Graphics)
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