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    Fabp4 fatty acid binding protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79451, updated on 19-Mar-2019

    Summary

    Official Symbol
    Fabp4provided by RGD
    Official Full Name
    fatty acid binding protein 4provided by RGD
    Primary source
    RGD:69309
    See related
    Ensembl:ENSRNOG00000010805
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    aP2; Albp
    Summary
    intracellular lipid-binding protein; mediates fatty acid trafficking during lipolysis [RGD, Feb 2006]
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Biased expression in Thymus (RPKM 8769.0), Adrenal (RPKM 8627.2) and 6 other tissues See more

    Genomic context

    See Fabp4 in Genome Data Viewer
    Location:
    2q23
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (93792666..93797267)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (113547703..113552304)

    Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene inositol monophosphatase 1 Neighboring gene fatty acid binding protein 12 Neighboring gene uncharacterized LOC108349977 Neighboring gene fatty acid binding protein 9 Neighboring gene peripheral myelin protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    fatty acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    fatty acid binding TAS
    Traceable Author Statement
    more info
    PubMed 
    hormone receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    long-chain fatty acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    long-chain fatty acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    long-chain fatty acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    long-chain fatty acid transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    long-chain fatty acid transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    long-chain fatty acid transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    brown fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    brown fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to lithium ion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to lithium ion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    cholesterol homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine production IEA
    Inferred from Electronic Annotation
    more info
     
    cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    long-chain fatty acid transport IEA
    Inferred from Electronic Annotation
    more info
     
    long-chain fatty acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    long-chain fatty acid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of fat cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to glucocorticoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    white fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    white fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid droplet TAS
    Traceable Author Statement
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    fatty acid-binding protein, adipocyte
    Names
    A-FABP
    AFABP
    adipocyte lipid-binding protein
    adipocyte-type fatty acid-binding protein
    fatty acid binding protein 4, adipocyte

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053365.1NP_445817.1  fatty acid-binding protein, adipocyte

      See identical proteins and their annotated locations for NP_445817.1

      Status: PROVISIONAL

      Source sequence(s)
      AF144756
      UniProtKB/TrEMBL
      Q9R290
      Related
      ENSRNOP00000014701.5, ENSRNOT00000014701.7
      Conserved Domains (1) summary
      pfam00061
      Location:6121
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

      Range
      93792666..93797267
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000070.1 Alternate Rn_Celera

      Range
      87183534..87187814
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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