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    Tram1 translocating chain-associating membrane protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 72265, updated on 7-Apr-2019

    Summary

    Official Symbol
    Tram1provided by MGI
    Official Full Name
    translocating chain-associating membrane protein 1provided by MGI
    Primary source
    MGI:MGI:1919515
    See related
    Ensembl:ENSMUSG00000025935
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TRAMP; 1810049E02Rik
    Summary
    This gene encodes a multi-pass transmembrane protein of the endoplasmic reticulum (ER). It is involved in the process of cotranslational translocation of secretory proteins into the ER. [provided by RefSeq, Dec 2014]
    Expression
    Ubiquitous expression in placenta adult (RPKM 47.6), testis adult (RPKM 32.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Tram1 in Genome Data Viewer
    Location:
    1; 1 A3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (13564693..13589910, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (13554783..13579945, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39595 Neighboring gene signal recognition particle receptor ('docking protein') pseudogene Neighboring gene predicted gene, 39600 Neighboring gene lactamase, beta 2 Neighboring gene X-linked Kx blood group related 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Pathways from BioSystems

    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • MGC1174

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    SRP-dependent cotranslational protein targeting to membrane, translocation IEA
    Inferred from Electronic Annotation
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    rough endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    translocating chain-associated membrane protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028173.5NP_082449.1  translocating chain-associated membrane protein 1

      See identical proteins and their annotated locations for NP_082449.1

      Status: REVIEWED

      Source sequence(s)
      AC157769
      Consensus CDS
      CCDS14822.1
      UniProtKB/Swiss-Prot
      Q91V04
      UniProtKB/TrEMBL
      Q4FK14
      Related
      ENSMUSP00000027068.4, ENSMUST00000027068.10
      Conserved Domains (2) summary
      smart00724
      Location:117326
      TLC; TRAM, LAG1 and CLN8 homology domains
      pfam08390
      Location:50115
      TRAM1; TRAM1-like protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      13564693..13589910 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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