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    NR2C1 nuclear receptor subfamily 2 group C member 1 [ Homo sapiens (human) ]

    Gene ID: 7181, updated on 15-Apr-2019

    Summary

    Official Symbol
    NR2C1provided by HGNC
    Official Full Name
    nuclear receptor subfamily 2 group C member 1provided by HGNC
    Primary source
    HGNC:HGNC:7971
    See related
    Ensembl:ENSG00000120798 MIM:601529
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TR2
    Summary
    This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 8.3), endometrium (RPKM 5.9) and 25 other tissues See more
    Orthologs

    Genomic context

    See NR2C1 in Genome Data Viewer
    Location:
    12q22
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (95020229..95073628, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (95414005..95467404, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369915 Neighboring gene NADH:ubiquinone oxidoreductase subunit A12 Neighboring gene uncharacterized LOC112268099 Neighboring gene peroxiredoxin 6 pseudogene Neighboring gene FYVE, RhoGEF and PH domain containing 6 Neighboring gene ribosomal protein L14 pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    matrix gag HIV-1 MA upregulates NR2C1 gene expression in HepG2 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific ISM
    Inferred from Sequence Model
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific NAS
    Non-traceable Author Statement
    more info
    PubMed 
    DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    steroid hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    PML body IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    nuclear receptor subfamily 2 group C member 1
    Names
    TR2 nuclear hormone receptor
    nuclear receptor subfamily 2, group C isoform
    orphan nuclear receptor TR2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001032287.2NP_001027458.1  nuclear receptor subfamily 2 group C member 1 isoform b

      See identical proteins and their annotated locations for NP_001027458.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR compared to variant 1. The resulting isoform (b, also known as TR2-9) has a shorter C-terminus compared to isoform a.
      Source sequence(s)
      BC040141, DB266298
      Consensus CDS
      CCDS41821.1
      UniProtKB/Swiss-Prot
      P13056
      UniProtKB/TrEMBL
      H9NIM3
      Related
      ENSP00000376813.3, ENST00000393101.7
      Conserved Domains (2) summary
      cd06967
      Location:108194
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
      cl11397
      Location:368464
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    2. NM_001127362.1NP_001120834.1  nuclear receptor subfamily 2 group C member 1 isoform c

      See identical proteins and their annotated locations for NP_001120834.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR compared to variant 1. The resulting isoform (c, also known as TR2-5) has a shorter C-terminus compared to isoform a.
      Source sequence(s)
      AK291319, BC040141, DB266298, M21985
      Consensus CDS
      CCDS44953.1
      UniProtKB/Swiss-Prot
      P13056
      Related
      ENSP00000328843.7, ENST00000330677.7
      Conserved Domains (2) summary
      cd06967
      Location:108194
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
      cl11397
      Location:368465
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    3. NM_003297.4NP_003288.2  nuclear receptor subfamily 2 group C member 1 isoform a

      See identical proteins and their annotated locations for NP_003288.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a, also known as TR2-11).
      Source sequence(s)
      AC011598, AK291319, DB266298, JQ308177
      Consensus CDS
      CCDS9051.1
      UniProtKB/Swiss-Prot
      P13056
      UniProtKB/TrEMBL
      H9NIM2
      Related
      ENSP00000333275.4, ENST00000333003.10
      Conserved Domains (2) summary
      cd06952
      Location:368589
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:108194
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

      Range
      95020229..95073628 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011538717.2XP_011537019.1  nuclear receptor subfamily 2 group C member 1 isoform X4

      Conserved Domains (2) summary
      cd06967
      Location:108194
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
      cl11397
      Location:322493
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    2. XM_006719584.2XP_006719647.1  nuclear receptor subfamily 2 group C member 1 isoform X2

      Conserved Domains (2) summary
      cd06967
      Location:108194
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
      cl11397
      Location:368543
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    3. XM_005269133.2XP_005269190.1  nuclear receptor subfamily 2 group C member 1 isoform X1

      Conserved Domains (2) summary
      cd06952
      Location:368584
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:108194
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
    4. XM_011538716.2XP_011537018.1  nuclear receptor subfamily 2 group C member 1 isoform X3

      Conserved Domains (2) summary
      cd06967
      Location:108194
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
      cl11397
      Location:368514
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    5. XM_006719585.2XP_006719648.1  nuclear receptor subfamily 2 group C member 1 isoform X5

      Conserved Domains (2) summary
      cd06952
      Location:191412
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cl02596
      Location:117
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    RNA

    1. XR_001748864.1 RNA Sequence

    2. XR_944699.2 RNA Sequence

    3. XR_429114.2 RNA Sequence

    4. XR_001748861.1 RNA Sequence

    5. XR_001748863.1 RNA Sequence

    6. XR_001748862.1 RNA Sequence

    7. XR_944700.1 RNA Sequence

    8. XR_245956.1 RNA Sequence

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