Format

Send to:

Choose Destination
    • Showing Current items.

    PML promyelocytic leukemia [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 700379, updated on 3-Apr-2017

    Summary

    Gene symbol
    PML
    Gene description
    promyelocytic leukemia
    See related
    Ensembl:ENSMMUG00000002569
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs

    Genomic context

    See PML in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    102 current Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (49820456..49874708, complement)
    Build 1.2 previous assembly Mmul_051212 (GCF_000002255.3) 7 NC_007864.1 (52679534..52731816)

    Chromosome 7 - NC_027899.1Genomic Context describing neighboring genes Neighboring gene ariadne RBR E3 ubiquitin protein ligase 1 Neighboring gene putative golgin subfamily A member 6C Neighboring gene stomatin like 1 Neighboring gene uncharacterized LOC106999235 Neighboring gene lysyl oxidase like 1

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    • Acute myeloid leukemia, organism-specific biosystem (from KEGG)
      Acute myeloid leukemia, organism-specific biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
    • Acute myeloid leukemia, conserved biosystem (from KEGG)
      Acute myeloid leukemia, conserved biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
      Transcriptional misregulation in cancer, organism-specific biosystem
      Transcriptional misregulation in cancer
    • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
      Transcriptional misregulation in cancer, conserved biosystem
      Transcriptional misregulation in cancer
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    protein PML
    Names
    promyelocytic leukemia protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042434.1NP_001035899.1  protein PML

      See identical proteins and their annotated locations for NP_001035899.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ231471
      UniProtKB/TrEMBL
      Q15JD4
      Conserved Domains (5) summary
      smart00336
      Location:129166
      BBOX; B-Box-type zinc finger
      pfam00097
      Location:5791
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam12126
      Location:240570
      DUF3583; Protein of unknown function (DUF3583)
      pfam14197
      Location:231300
      Cep57_CLD_2; Centrosome localization domain of PPC89
      cl10012
      Location:610758
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_8.0.1 Primary Assembly

    Genomic

    1. NC_027899.1 Reference Mmul_8.0.1 Primary Assembly

      Range
      49820456..49874708 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015142614.1XP_014998100.1  protein PML isoform X1

      UniProtKB/TrEMBL
      H9ZA72
      Related
      ENSMMUP00000056983.1, ENSMMUT00000071685.1
      Conserved Domains (5) summary
      smart00336
      Location:129166
      BBOX; B-Box-type zinc finger
      pfam00097
      Location:5791
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam12126
      Location:240522
      DUF3583; Protein of unknown function (DUF3583)
      pfam14197
      Location:231300
      Cep57_CLD_2; Centrosome localization domain of PPC89
      cl10012
      Location:562710
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    2. XM_015142617.1XP_014998103.1  protein PML isoform X4

      Conserved Domains (4) summary
      smart00336
      Location:129166
      BBOX; B-Box-type zinc finger
      pfam00097
      Location:5791
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam12126
      Location:240570
      DUF3583; Protein of unknown function (DUF3583)
      pfam14197
      Location:231300
      Cep57_CLD_2; Centrosome localization domain of PPC89
    3. XM_015142623.1XP_014998109.1  protein PML isoform X8

      UniProtKB/TrEMBL
      F7HSN0
      Related
      ENSMMUP00000003458.3, ENSMMUT00000003659.3
      Conserved Domains (3) summary
      pfam00097
      Location:5791
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam12126
      Location:240418
      DUF3583; Protein of unknown function (DUF3583)
      pfam14197
      Location:231300
      Cep57_CLD_2; Centrosome localization domain of PPC89
    4. XM_015142622.1XP_014998108.1  protein PML isoform X7

      Related
      ENSMMUP00000003455.3, ENSMMUT00000003656.3
      Conserved Domains (3) summary
      pfam00097
      Location:5791
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam12126
      Location:240504
      DUF3583; Protein of unknown function (DUF3583)
      pfam14197
      Location:231300
      Cep57_CLD_2; Centrosome localization domain of PPC89
    5. XM_015142619.1XP_014998105.1  protein PML isoform X6

      Conserved Domains (4) summary
      smart00336
      Location:129166
      BBOX; B-Box-type zinc finger
      pfam00097
      Location:5791
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam12126
      Location:240552
      DUF3583; Protein of unknown function (DUF3583)
      pfam14197
      Location:231300
      Cep57_CLD_2; Centrosome localization domain of PPC89
    6. XM_015142616.1XP_014998102.1  protein PML isoform X3

      Conserved Domains (4) summary
      smart00336
      Location:129166
      BBOX; B-Box-type zinc finger
      pfam00097
      Location:5791
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam12126
      Location:240522
      DUF3583; Protein of unknown function (DUF3583)
      pfam14197
      Location:231300
      Cep57_CLD_2; Centrosome localization domain of PPC89
    7. XM_015142618.1XP_014998104.1  protein PML isoform X5

      Conserved Domains (4) summary
      smart00336
      Location:129166
      BBOX; B-Box-type zinc finger
      pfam00097
      Location:5791
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam12126
      Location:240570
      DUF3583; Protein of unknown function (DUF3583)
      pfam14197
      Location:231300
      Cep57_CLD_2; Centrosome localization domain of PPC89
    8. XM_015142615.1XP_014998101.1  protein PML isoform X2

      UniProtKB/TrEMBL
      F7HSN1
      Related
      ENSMMUP00000003457.3, ENSMMUT00000003658.3
      Conserved Domains (4) summary
      smart00336
      Location:129166
      BBOX; B-Box-type zinc finger
      pfam00097
      Location:5791
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam12126
      Location:240570
      DUF3583; Protein of unknown function (DUF3583)
      pfam14197
      Location:231300
      Cep57_CLD_2; Centrosome localization domain of PPC89
    9. XM_015142621.1XP_014998107.1  protein PML isoform X6

      Conserved Domains (4) summary
      smart00336
      Location:129166
      BBOX; B-Box-type zinc finger
      pfam00097
      Location:5791
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam12126
      Location:240552
      DUF3583; Protein of unknown function (DUF3583)
      pfam14197
      Location:231300
      Cep57_CLD_2; Centrosome localization domain of PPC89
    10. XM_015142625.1XP_014998111.1  protein PML isoform X8

      UniProtKB/TrEMBL
      F7HSN0
      Related
      ENSMMUP00000003453.3, ENSMMUT00000003654.3
      Conserved Domains (3) summary
      pfam00097
      Location:5791
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam12126
      Location:240418
      DUF3583; Protein of unknown function (DUF3583)
      pfam14197
      Location:231300
      Cep57_CLD_2; Centrosome localization domain of PPC89
    11. XM_015142620.1XP_014998106.1  protein PML isoform X6

      Conserved Domains (4) summary
      smart00336
      Location:129166
      BBOX; B-Box-type zinc finger
      pfam00097
      Location:5791
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam12126
      Location:240552
      DUF3583; Protein of unknown function (DUF3583)
      pfam14197
      Location:231300
      Cep57_CLD_2; Centrosome localization domain of PPC89
    12. XM_015142626.1XP_014998112.1  protein PML isoform X9

      Conserved Domains (3) summary
      pfam00097
      Location:5791
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam12126
      Location:240418
      DUF3583; Protein of unknown function (DUF3583)
      pfam14197
      Location:231300
      Cep57_CLD_2; Centrosome localization domain of PPC89
    Support Center