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    Vrk2 vaccinia related kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 69922, updated on 31-Jan-2019

    Summary

    Official Symbol
    Vrk2provided by MGI
    Official Full Name
    vaccinia related kinase 2provided by MGI
    Primary source
    MGI:MGI:1917172
    See related
    Ensembl:ENSMUSG00000064090
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI447698; 2810003O05Rik
    Expression
    Broad expression in liver E14 (RPKM 6.6), liver E14.5 (RPKM 4.9) and 24 other tissues See more
    Orthologs

    Genomic context

    See Vrk2 in Genome Data Viewer
    Location:
    11; 11 A3.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (26471398..26594014, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (26371401..26493920, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 31023 Neighboring gene transmembrane protein 85 pseudogene Neighboring gene Fanconi anemia, complementation group L Neighboring gene peptidylprolyl isomerase A pseudogene 11_266.1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-threonine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of interleukin-1-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase VRK2
    Names
    vaccinia virus BIR kinase related kinase 2
    NP_001239376.1
    NP_081536.2
    XP_006514864.1
    XP_011242050.1
    XP_017170237.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252447.1NP_001239376.1  serine/threonine-protein kinase VRK2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment in the C-terminal region, compared to isoform 1.
      Source sequence(s)
      AC083815, AL929272
      UniProtKB/Swiss-Prot
      Q8BN21
      Conserved Domains (2) summary
      pfam00069
      Location:29292
      Pkinase; Protein kinase domain
      cl21453
      Location:16314
      PKc_like; Protein Kinases, catalytic domain
    2. NM_027260.3NP_081536.2  serine/threonine-protein kinase VRK2 isoform 1

      See identical proteins and their annotated locations for NP_081536.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AF513620, BB852723, BE984366
      Consensus CDS
      CCDS24486.1
      UniProtKB/Swiss-Prot
      Q8BN21
      Related
      ENSMUSP00000077471.6, ENSMUST00000078362.12
      Conserved Domains (2) summary
      COG0515
      Location:29421
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cl21453
      Location:16314
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      26471398..26594014 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514801.3XP_006514864.1  serine/threonine-protein kinase VRK2 isoform X1

      See identical proteins and their annotated locations for XP_006514864.1

      UniProtKB/Swiss-Prot
      Q8BN21
      Related
      ENSMUSP00000105130.1, ENSMUST00000109504.7
      Conserved Domains (2) summary
      COG0515
      Location:29421
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cl21453
      Location:16314
      PKc_like; Protein Kinases, catalytic domain
    2. XM_017314748.1XP_017170237.1  serine/threonine-protein kinase VRK2 isoform X2

      Conserved Domains (2) summary
      COG0515
      Location:1303
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cl21453
      Location:1196
      PKc_like; Protein Kinases, catalytic domain
    3. XM_011243748.2XP_011242050.1  serine/threonine-protein kinase VRK2 isoform X2

      Conserved Domains (2) summary
      COG0515
      Location:1303
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cl21453
      Location:1196
      PKc_like; Protein Kinases, catalytic domain
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