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    TCF7 transcription factor 7 [ Homo sapiens (human) ]

    Gene ID: 6932, updated on 21-Apr-2019

    Summary

    Official Symbol
    TCF7provided by HGNC
    Official Full Name
    transcription factor 7provided by HGNC
    Primary source
    HGNC:HGNC:11639
    See related
    Ensembl:ENSG00000081059 MIM:189908
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TCF-1
    Summary
    This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling. [provided by RefSeq, Oct 2016]
    Expression
    Broad expression in lymph node (RPKM 9.2), appendix (RPKM 6.3) and 14 other tissues See more
    Orthologs

    Genomic context

    See TCF7 in Genome Data Viewer
    Location:
    5q31.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (134114698..134148229)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (133450402..133483920)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene voltage dependent anion channel 1 Neighboring gene uncharacterized LOC105379185 Neighboring gene short transmembrane mitochondrial protein 1-like Neighboring gene S-phase kinase associated protein 1 Neighboring gene protein phosphatase 2 catalytic subunit alpha Neighboring gene microRNA 3661

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    NHGRI GWA Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Acute myeloid leukemia, organism-specific biosystem (from KEGG)
      Acute myeloid leukemia, organism-specific biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
    • Acute myeloid leukemia, conserved biosystem (from KEGG)
      Acute myeloid leukemia, conserved biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
    • Adherens junction, organism-specific biosystem (from KEGG)
      Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junction, conserved biosystem (from KEGG)
      Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Amplification and Expansion of Oncogenic Pathways as Metastatic Traits, organism-specific biosystem (from WikiPathways)
      Amplification and Expansion of Oncogenic Pathways as Metastatic Traits, organism-specific biosystemThis pathway is based on Figure 4 of "Origins of metastatic traits."(See Bibliography).The majority of cancer cells released from tumors die off, so cancer biologists are trying to figure out exactly...
    • Arrhythmogenic Right Ventricular Cardiomyopathy, organism-specific biosystem (from WikiPathways)
      Arrhythmogenic Right Ventricular Cardiomyopathy, organism-specific biosystemAdapted from KEGG: http://www.genome.jp/kegg/pathway/hsa/hsa05412.html
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Basal cell carcinoma, organism-specific biosystem (from KEGG)
      Basal cell carcinoma, organism-specific biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
    • Basal cell carcinoma, conserved biosystem (from KEGG)
      Basal cell carcinoma, conserved biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
    • Beta-catenin independent WNT signaling, organism-specific biosystem (from REACTOME)
      Beta-catenin independent WNT signaling, organism-specific biosystemHumans and mice have 19 identified WNT proteins that were originally classified as either 'canonical' or 'non-canonical' depending upon whether they were able to transform the mouse mammary epithelia...
    • Binding of TCF/LEF:CTNNB1 to target gene promoters, organism-specific biosystem (from REACTOME)
      Binding of TCF/LEF:CTNNB1 to target gene promoters, organism-specific biosystemThe genes regulated by beta-catenin and TCF/LEF are involved in a diverse range of functions in cellular proliferation, differentiation, embryogenesis and tissue homeostasis, and include transcriptio...
    • Breast cancer, organism-specific biosystem (from KEGG)
      Breast cancer, organism-specific biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
    • Breast cancer, conserved biosystem (from KEGG)
      Breast cancer, conserved biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
    • Ca2+ pathway, organism-specific biosystem (from REACTOME)
      Ca2+ pathway, organism-specific biosystemA number of so called non-canonical WNT ligands have been shown to promote intracellular calcium release upon FZD binding. This beta-catenin-independent WNT pathway acts through heterotrimeric G pro...
    • Colorectal cancer, organism-specific biosystem (from KEGG)
      Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Colorectal cancer, conserved biosystem (from KEGG)
      Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • DNA Damage Response (only ATM dependent), organism-specific biosystem (from WikiPathways)
      DNA Damage Response (only ATM dependent), organism-specific biosystemThis is the second pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and TP53) which are connected with the first DNA damage response pathway. In...
    • Deactivation of the beta-catenin transactivating complex, organism-specific biosystem (from REACTOME)
      Deactivation of the beta-catenin transactivating complex, organism-specific biosystemThe mechanisms involved in downregulation of TCF-dependent transcription are not yet very well understood. beta-catenin is known to recruit a number of transcriptional repressors, including Reptin, S...
    • Degradation of beta-catenin by the destruction complex, organism-specific biosystem (from REACTOME)
      Degradation of beta-catenin by the destruction complex, organism-specific biosystemThe beta-catenin destruction complex plays a key role in the canonical Wnt signaling pathway. In the absence of Wnt signaling, this complex controls the levels of cytoplamic beta-catenin. Beta-cateni...
    • Endoderm Differentiation, organism-specific biosystem (from WikiPathways)
      Endoderm Differentiation, organism-specific biosystemModel depicting endoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lin...
    • Endometrial cancer, organism-specific biosystem (from KEGG)
      Endometrial cancer, organism-specific biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
    • Endometrial cancer, conserved biosystem (from KEGG)
      Endometrial cancer, conserved biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
    • Formation of the beta-catenin:TCF transactivating complex, organism-specific biosystem (from REACTOME)
      Formation of the beta-catenin:TCF transactivating complex, organism-specific biosystemOnce in the nucleus, beta-catenin is recruited to WNT target genes through interaction with TCF/LEF transcription factors. This family, which consists of TCF7 (also known as TCF1), TCF7L1 (also known...
    • Hippo signaling pathway, organism-specific biosystem (from KEGG)
      Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Hippo signaling pathway, conserved biosystem (from KEGG)
      Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Melanogenesis, organism-specific biosystem (from KEGG)
      Melanogenesis, organism-specific biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
    • Melanogenesis, conserved biosystem (from KEGG)
      Melanogenesis, conserved biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Prostate cancer, organism-specific biosystem (from KEGG)
      Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Prostate cancer, conserved biosystem (from KEGG)
      Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem
      Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    • Repression of WNT target genes, organism-specific biosystem (from REACTOME)
      Repression of WNT target genes, organism-specific biosystemIn the absence of a WNT signal, many WNT target genes are repressed by Groucho/TLE. Groucho was initially identified in Drosophila, where it has been shown to interact with a variety of proteins to ...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Wnt, organism-specific biosystem (from REACTOME)
      Signaling by Wnt, organism-specific biosystemWNT signaling pathways control a wide range of developmental and adult process in metozoans including cell proliferation, cell fate decisions, cell polarity and stem cell maintenance (reviewed in Sai...
    • TCF dependent signaling in response to WNT, organism-specific biosystem (from REACTOME)
      TCF dependent signaling in response to WNT, organism-specific biosystem19 WNT ligands and 10 FZD receptors have been identified in human cells; interactions amongst these ligands and receptors vary in a developmental and tissue-specific manner and lead to activation of ...
    • Thyroid cancer, organism-specific biosystem (from KEGG)
      Thyroid cancer, organism-specific biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
    • Thyroid cancer, conserved biosystem (from KEGG)
      Thyroid cancer, conserved biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
    • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell plurip...
    • Wnt signaling, organism-specific biosystem (from KEGG)
      Wnt signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
    • Wnt signaling, conserved biosystem (from KEGG)
      Wnt signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ36364, MGC47735

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    T cell receptor V(D)J recombination IEA
    Inferred from Electronic Annotation
    more info
     
    alpha-beta T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    beta-catenin-TCF complex assembly TAS
    Traceable Author Statement
    more info
     
    canonical Wnt signaling pathway involved in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to interleukin-4 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    embryonic digestive tract morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic genitalia morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic hindgut morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    neural tube development IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nuclear body IDA
    Inferred from Direct Assay
    more info
     
    nuclear euchromatin IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription factor 7
    Names
    T-cell-factor-7
    T-cell-specific transcription factor 1
    transcription factor 7 (T-cell specific, HMG-box)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030367.1 RefSeqGene

      Range
      4988..38519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001134851.3NP_001128323.2  transcription factor 7 isoform 3

      See identical proteins and their annotated locations for NP_001128323.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as A), differs in the 5' UTR, has multiple coding region differences, uses a downstream start codon, and differs in the 3' UTR, compared to variant 1. The resulting isoform (3) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC008608, AC011336, HY048657, X59869, X59871
      Consensus CDS
      CCDS47263.2
      UniProtKB/Swiss-Prot
      P36402
      Related
      ENSP00000430179.1, ENST00000518915.5
      Conserved Domains (2) summary
      cd01388
      Location:154224
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:197
      CTNNB1_binding; N-terminal CTNNB1 binding
    2. NM_001346425.1NP_001333354.1  transcription factor 7 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) contains an alternate exon in the coding region, compared to variant 1. The resulting isoform (5) is longer, compared to isoform 1.
      Source sequence(s)
      AC008608, AC011336, AK057580, AL832816, BC048769, CR976030, X59870
      UniProtKB/Swiss-Prot
      P36402
      UniProtKB/TrEMBL
      B3KQ75
    3. NM_001346450.1NP_001333379.1  transcription factor 7 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR, has multiple coding region differences, and uses a downstream start codon, compared to variant 1. The resulting isoform (7) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC008608, AC011336, CN274309, DB128524, X59871
      UniProtKB/Swiss-Prot
      P36402
    4. NM_001366502.1NP_001353431.1  transcription factor 7 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC011336, AK310591, DB137814
      Conserved Domains (2) summary
      cd01388
      Location:129199
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:1272
      CTNNB1_binding; N-terminal CTNNB1 binding
    5. NM_003202.5NP_003193.2  transcription factor 7 isoform 1

      See identical proteins and their annotated locations for NP_003193.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform (1).
      Source sequence(s)
      AC008608, AC011336, AK057580, AL832816, BC048769, X59870
      Consensus CDS
      CCDS4169.1
      UniProtKB/Swiss-Prot
      P36402
      UniProtKB/TrEMBL
      B3KQ75
      Related
      ENSP00000340347.5, ENST00000342854.10
      Conserved Domains (2) summary
      cd01388
      Location:269339
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:20212
      CTNNB1_binding; N-terminal CTNNB1 binding
    6. NM_201632.4NP_963963.1  transcription factor 7 isoform 2

      See identical proteins and their annotated locations for NP_963963.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as B), differs in the 5' UTR, has multiple coding region differences, and uses a downstream start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 5 encode the same isoform.
      Source sequence(s)
      AC008608, AC011336, AK057580, BC048769, DB106996, HY048657, X59870
      Consensus CDS
      CCDS4170.1
      UniProtKB/Swiss-Prot
      P36402
      UniProtKB/TrEMBL
      B3KQ75
      Related
      ENSP00000378469.1, ENST00000395023.5
      Conserved Domains (2) summary
      cd01388
      Location:154224
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:197
      CTNNB1_binding; N-terminal CTNNB1 binding
    7. NM_201634.4NP_963965.1  transcription factor 7 isoform 4

      See identical proteins and their annotated locations for NP_963965.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also known as C), differs in the 5' UTR, has multiple coding region differences, uses a downstream start codon, and differs in the 3' UTR, compared to variant 1. The resulting isoform (4) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC008608, AC011336, CN274309, HY048657, X59871
      Consensus CDS
      CCDS43362.1
      UniProtKB/Swiss-Prot
      P36402
      Related
      ENSP00000367822.4, ENST00000378560.8
      Conserved Domains (2) summary
      cd01388
      Location:154224
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:197
      CTNNB1_binding; N-terminal CTNNB1 binding
    8. NM_213648.4NP_998813.1  transcription factor 7 isoform 2

      See identical proteins and their annotated locations for NP_998813.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, has multiple coding region differences, and uses a downstream start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 5 encode the same isoform.
      Source sequence(s)
      AC008608, AC011336, AK057580, AL832816, BC048769, DB137814, DB161143, X59870
      Consensus CDS
      CCDS4170.1
      UniProtKB/Swiss-Prot
      P36402
      UniProtKB/TrEMBL
      B3KQ75
      Related
      ENSP00000429547.1, ENST00000520958.5
      Conserved Domains (2) summary
      cd01388
      Location:154224
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:197
      CTNNB1_binding; N-terminal CTNNB1 binding

    RNA

    1. NR_033449.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate 5' exon structure and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC008608, AC011336, AK057580, X59870

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

      Range
      134114698..134148229
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006714682.2XP_006714745.1  transcription factor 7 isoform X5

      Conserved Domains (2) summary
      cd01388
      Location:300370
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:20212
      CTNNB1_binding; N-terminal CTNNB1 binding
    2. XM_006714684.2XP_006714747.1  transcription factor 7 isoform X6

      UniProtKB/Swiss-Prot
      P36402
      Conserved Domains (2) summary
      cd01388
      Location:269339
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:20212
      CTNNB1_binding; N-terminal CTNNB1 binding
    3. XM_011543606.1XP_011541908.1  transcription factor 7 isoform X4

      Conserved Domains (2) summary
      cd01388
      Location:300370
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:20212
      CTNNB1_binding; N-terminal CTNNB1 binding
    4. XM_011543604.2XP_011541906.1  transcription factor 7 isoform X3

      Conserved Domains (2) summary
      cd01388
      Location:300370
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:20212
      CTNNB1_binding; N-terminal CTNNB1 binding
    5. XM_006714678.3XP_006714741.1  transcription factor 7 isoform X1

      Conserved Domains (2) summary
      cd01388
      Location:300370
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:20212
      CTNNB1_binding; N-terminal CTNNB1 binding
    6. XM_006714679.3XP_006714742.1  transcription factor 7 isoform X2

      Conserved Domains (2) summary
      cd01388
      Location:269339
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:20212
      CTNNB1_binding; N-terminal CTNNB1 binding
    7. XM_006714685.4XP_006714748.1  transcription factor 7 isoform X7

      Conserved Domains (2) summary
      cd01388
      Location:185255
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:197
      CTNNB1_binding; N-terminal CTNNB1 binding
    8. XM_006714686.4XP_006714749.1  transcription factor 7 isoform X10

      Conserved Domains (2) summary
      cd01388
      Location:154224
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:197
      CTNNB1_binding; N-terminal CTNNB1 binding
    9. XM_011543613.3XP_011541915.1  transcription factor 7 isoform X13

      Conserved Domains (1) summary
      cd01388
      Location:67137
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    10. XM_011543608.2XP_011541910.1  transcription factor 7 isoform X9

      Conserved Domains (2) summary
      cd01388
      Location:160230
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:1272
      CTNNB1_binding; N-terminal CTNNB1 binding
    11. XM_011543612.2XP_011541914.1  transcription factor 7 isoform X12

      Conserved Domains (2) summary
      cd01388
      Location:129199
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:1272
      CTNNB1_binding; N-terminal CTNNB1 binding
    12. XM_011543609.2XP_011541911.1  transcription factor 7 isoform X11

      Conserved Domains (2) summary
      cd01388
      Location:129199
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:1272
      CTNNB1_binding; N-terminal CTNNB1 binding
    13. XM_011543607.2XP_011541909.1  transcription factor 7 isoform X8

      Conserved Domains (2) summary
      cd01388
      Location:181251
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:3393
      CTNNB1_binding; N-terminal CTNNB1 binding
    14. XM_017009790.1XP_016865279.1  transcription factor 7 isoform X14

    RNA

    1. XR_948292.1 RNA Sequence

      Related
      ENST00000395029.5
    2. XR_001742232.1 RNA Sequence

    3. XR_001742231.1 RNA Sequence

    4. XR_948294.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001134852.1: Suppressed sequence

      Description
      NM_001134852.1: This RefSeq was temporarily suppressed because the CDS may possibly be 5'-partial, and the nature of its 5' end is unclear.
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