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    Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 68652, updated on 19-Mar-2019

    Summary

    Official Symbol
    Tab2provided by MGI
    Official Full Name
    TGF-beta activated kinase 1/MAP3K7 binding protein 2provided by MGI
    Primary source
    MGI:MGI:1915902
    See related
    Ensembl:ENSMUSG00000015755
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Map3k7ip2; mKIAA0733; 1110030N06Rik; A530078N03Rik
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 18.4), CNS E11.5 (RPKM 13.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Tab2 in Genome Data Viewer
    Location:
    10; 10 A1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (7905648..7956653, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (7625446..7675921, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase (cyclophilin)-like 4 Neighboring gene zinc finger CCCH type containing 12D Neighboring gene microRNA 5104 Neighboring gene predicted gene, 30820 Neighboring gene predicted gene, 30906 Neighboring gene predicted gene, 30959

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    K63-linked polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    heart development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
    Names
    TGF-beta-activated kinase 1-binding protein 2
    Tak1 binding protein 2
    mitogen-activated protein kinase kinase kinase 7-interacting protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359534.1NP_001346463.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

      Status: VALIDATED

      Source sequence(s)
      AC092856, AW492243, AY093701, CN532534
      Conserved Domains (4) summary
      smart00547
      Location:667690
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:668687
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cl25732
      Location:537614
      SMC_N; RecF/RecN/SMC N terminal domain
    2. NM_138667.3NP_619608.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

      See identical proteins and their annotated locations for NP_619608.1

      Status: VALIDATED

      Source sequence(s)
      AC092856, AK003993, AY093701, BF468714, BG078791, BY429748, CK391470
      Consensus CDS
      CCDS23691.1
      UniProtKB/Swiss-Prot
      Q99K90
      Related
      ENSMUSP00000121266.1, ENSMUST00000146444.7
      Conserved Domains (4) summary
      smart00547
      Location:667690
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:668687
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cl25732
      Location:537614
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      7905648..7956653 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243204.2XP_011241506.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011241506.1

      Conserved Domains (4) summary
      smart00547
      Location:693716
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:694713
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cl00087
      Location:561628
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    2. XM_011243203.2XP_011241505.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011241505.1

      Conserved Domains (4) summary
      smart00547
      Location:693716
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:694713
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cl00087
      Location:561628
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    3. XM_017314073.1XP_017169562.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q99K90
      Conserved Domains (4) summary
      smart00547
      Location:667690
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:668687
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cl25732
      Location:537614
      SMC_N; RecF/RecN/SMC N terminal domain
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