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    Tab3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 66724, updated on 31-Jan-2019

    Summary

    Official Symbol
    Tab3provided by MGI
    Official Full Name
    TGF-beta activated kinase 1/MAP3K7 binding protein 3provided by MGI
    Primary source
    MGI:MGI:1913974
    See related
    Ensembl:ENSMUSG00000035476
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Map3k7ip3; mKIAA4135; 4921526G09Rik
    Expression
    Ubiquitous expression in liver E14 (RPKM 4.3), placenta adult (RPKM 4.2) and 27 other tissues See more
    Orthologs

    Genomic context

    See Tab3 in Genome Data Viewer
    Location:
    X; X C1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (85573851..85634469)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (82819361..82879808)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16463 Neighboring gene ferritin, heavy polypeptide-like 17, member A Neighboring gene predicted gene, 39523 Neighboring gene RIKEN cDNA 5430427O19 gene Neighboring gene replication protein A 14 kDa subunit pseudogene Neighboring gene glycerol kinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • KIAA4135

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
    Names
    TAK1-binding protein 3
    TGF-beta-activated kinase 1-binding protein 3
    mitogen-activated protein kinase kinase kinase 7-interacting protein 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358447.1NP_001345376.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

      Status: VALIDATED

      Source sequence(s)
      AL645567, AL645586, BC090666
      Conserved Domains (3) summary
      smart00547
      Location:691713
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:691710
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
    2. NM_025729.4NP_080005.2  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

      See identical proteins and their annotated locations for NP_080005.2

      Status: VALIDATED

      Source sequence(s)
      AK048222, AK220185, BC090666
      Consensus CDS
      CCDS41049.1
      UniProtKB/Swiss-Prot
      Q571K4
      UniProtKB/TrEMBL
      B1ASY9, Q9D5S8
      Related
      ENSMUSP00000039668.3, ENSMUST00000048250.9
      Conserved Domains (3) summary
      smart00547
      Location:691713
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:691710
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      85573851..85634469
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318604.1XP_017174093.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q571K4
      UniProtKB/TrEMBL
      B1ASY9
      Conserved Domains (3) summary
      smart00547
      Location:691713
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:691710
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
    2. XM_006528238.3XP_006528301.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006528301.1

      UniProtKB/Swiss-Prot
      Q571K4
      UniProtKB/TrEMBL
      B1ASY9
      Conserved Domains (3) summary
      smart00547
      Location:691713
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:691710
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
    3. XM_006528239.2XP_006528302.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006528302.1

      UniProtKB/Swiss-Prot
      Q571K4
      UniProtKB/TrEMBL
      B1ASY9
      Conserved Domains (3) summary
      smart00547
      Location:691713
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:691710
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
    4. XM_017318605.1XP_017174094.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X2

      Conserved Domains (2) summary
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      pfam03153
      Location:122291
      TFIIA; Transcription factor IIA, alpha/beta subunit
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