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    Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 66513, updated on 5-Feb-2019

    Summary

    Official Symbol
    Tab1provided by MGI
    Official Full Name
    TGF-beta activated kinase 1/MAP3K7 binding protein 1provided by MGI
    Primary source
    MGI:MGI:1913763
    See related
    Ensembl:ENSMUSG00000022414
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Map3k7ip1; b2b449Clo; 2310012M03Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 16.5), ovary adult (RPKM 14.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Tab1 in Genome Data Viewer
    Location:
    15; 15 E1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (80133154..80161707)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (79963584..79992132)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 43 Neighboring gene ribosomal protein L3 Neighboring gene predicted gene, 31134 Neighboring gene synaptogyrin 1 Neighboring gene predicted gene, 31253 Neighboring gene mannoside acetylglucosaminyltransferase 3 Neighboring gene predicted gene, 46521 Neighboring gene ribosomal protein S2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Chemically induced (ENU) (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    magnesium-dependent protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitogen-activated protein kinase p38 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitogen-activated protein kinase p38 binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    activation of MAPKKK activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    aorta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac septum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    coronary vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
    Names
    Tak1-binding protein 1
    mitogen-activated protein kinase kinase kinase 7-interacting protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025609.3NP_079885.2  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

      See identical proteins and their annotated locations for NP_079885.2

      Status: VALIDATED

      Source sequence(s)
      BC054369, BQ176587, BY262560
      Consensus CDS
      CCDS27659.1
      UniProtKB/Swiss-Prot
      Q8CF89
      Related
      ENSMUSP00000023050.7, ENSMUST00000023050.8
      Conserved Domains (1) summary
      pfam00481
      Location:69334
      PP2C; Protein phosphatase 2C

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      80133154..80161707
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521259.2XP_006521322.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1

      Conserved Domains (1) summary
      cl00120
      Location:1168
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
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