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    mapk14a mitogen-activated protein kinase 14a [ Danio rerio (zebrafish) ]

    Gene ID: 65237, updated on 24-Mar-2019

    Summary

    Official Symbol
    mapk14aprovided by ZNC
    Official Full Name
    mitogen-activated protein kinase 14aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010202-2
    See related
    Ensembl:ENSDARG00000000857
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
    Also known as
    p38; p38a; zp38a; MAPK14; fk28c03; zeh1243; hm:zeh1243; wu:fk28c03

    Genomic context

    See mapk14a in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (23827441..23860719)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (23806189..23839480)
    103 previous assembly Zv9 (GCF_000002035.4) 8 NC_007119.5 (24680384..24713662)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene si:ch211-163l21.8 Neighboring gene si:ch211-163l21.10 Neighboring gene SRSF protein kinase 1a Neighboring gene LHFPL tetraspan subfamily member 5b

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    • Homologs of the mapk14a gene: The mapk14a gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
    • Orthologs

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular response to UV IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to organic substance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    embryonic cleavage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    p38MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    p38MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    p38MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of myoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of myoblast fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of myotube differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of collateral sprouting in absence of injury IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of collateral sprouting in absence of injury IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    mitogen-activated protein kinase 14A
    Names
    MAP kinase 14A
    MAP kinase p38a
    MAPK 14A
    etID18993.8
    mitogen-activated protein kinase p38a
    NP_571797.1
    XP_005167118.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131722.1NP_571797.1  mitogen-activated protein kinase 14A

      See identical proteins and their annotated locations for NP_571797.1

      Status: PROVISIONAL

      Source sequence(s)
      AB030897
      UniProtKB/Swiss-Prot
      Q9DGE2
      UniProtKB/TrEMBL
      B2GPM7
      Related
      ENSDARP00000040361.4, ENSDART00000040362.5
      Conserved Domains (2) summary
      cd07877
      Location:7351
      STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)
      smart00220
      Location:25309
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      23827441..23860719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167061.4XP_005167118.1  mitogen-activated protein kinase 14A isoform X1

      Related
      ENSDARP00000147688.1, ENSDART00000187430.1
      Conserved Domains (2) summary
      cd07877
      Location:7351
      STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)
      smart00220
      Location:25309
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394724.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      80447..114580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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