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    Bad BCL2-associated agonist of cell death [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64639, updated on 18-Apr-2019

    Summary

    Symbol
    Badprovided by RGD
    Full Name
    BCL2-associated agonist of cell deathprovided by RGD
    Primary source
    RGD:620103
    See related
    Ensembl:ENSRNOG00000021147
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bad_v1; Bad_v2
    Summary
    may be involved in induction of programmed cell death [RGD, Feb 2006]
    Expression
    Biased expression in Kidney (RPKM 91.8), Brain (RPKM 86.8) and 9 other tissues See more
    Orthologs

    Genomic context

    See Bad in Genome Data Viewer
    Location:
    1q43
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (222198516..222207459)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (229189271..229198306)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene potassium two pore domain channel subfamily K member 4 Neighboring gene G protein-coupled receptor 137 Neighboring gene phospholipase C beta 3 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 14B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Activation of BAD and translocation to mitochondria, organism-specific biosystem (from REACTOME)
      Activation of BAD and translocation to mitochondria, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Activation of BH3-only proteins, organism-specific biosystem (from REACTOME)
      Activation of BH3-only proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Acute myeloid leukemia, organism-specific biosystem (from KEGG)
      Acute myeloid leukemia, organism-specific biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
    • Acute myeloid leukemia, conserved biosystem (from KEGG)
      Acute myeloid leukemia, conserved biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
    • Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem
      Alpha6-Beta4 Integrin Signaling Pathway
    • Alzheimer's disease, organism-specific biosystem (from KEGG)
      Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimer's disease, conserved biosystem (from KEGG)
      Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), organism-specific biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Amyotrophic lateral sclerosis (ALS), conserved biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), conserved biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Autophagy - animal, organism-specific biosystem (from KEGG)
      Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - animal, conserved biosystem (from KEGG)
      Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, organism-specific biosystem (from REACTOME)
      BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem (from REACTOME)
      Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
      Chronic myeloid leukemia, organism-specific biosystemChronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (C...
    • Chronic myeloid leukemia, conserved biosystem (from KEGG)
      Chronic myeloid leukemia, conserved biosystemChronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (C...
    • Colorectal cancer, organism-specific biosystem (from KEGG)
      Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Colorectal cancer, conserved biosystem (from KEGG)
      Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • EGFR tyrosine kinase inhibitor resistance, organism-specific biosystem (from KEGG)
      EGFR tyrosine kinase inhibitor resistance, organism-specific biosystemEGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which ...
    • EGFR tyrosine kinase inhibitor resistance, conserved biosystem (from KEGG)
      EGFR tyrosine kinase inhibitor resistance, conserved biosystemEGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which ...
    • Endocrine resistance, organism-specific biosystem (from KEGG)
      Endocrine resistance, organism-specific biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
    • Endocrine resistance, conserved biosystem (from KEGG)
      Endocrine resistance, conserved biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
    • Endometrial cancer, organism-specific biosystem (from KEGG)
      Endometrial cancer, organism-specific biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
    • Endometrial cancer, conserved biosystem (from KEGG)
      Endometrial cancer, conserved biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
    • ErbB signaling pathway, organism-specific biosystem (from KEGG)
      ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • ErbB signaling pathway, conserved biosystem (from KEGG)
      ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • ErbB signaling pathway, organism-specific biosystem (from WikiPathways)
      ErbB signaling pathway, organism-specific biosystemThe ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with ...
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Hepatitis B, organism-specific biosystem (from KEGG)
      Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
    • Hepatitis C, organism-specific biosystem (from KEGG)
      Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Hepatitis C, conserved biosystem (from KEGG)
      Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
    • IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-6 Signaling Pathway, organism-specific biosystem
      IL-6 Signaling Pathway
    • Insulin signaling pathway, organism-specific biosystem (from KEGG)
      Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Insulin signaling pathway, conserved biosystem (from KEGG)
      Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Intrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
      Intrinsic Pathway for Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Kit Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Kit Receptor Signaling Pathway, organism-specific biosystemKit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets...
    • Melanoma, organism-specific biosystem (from KEGG)
      Melanoma, organism-specific biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • Melanoma, conserved biosystem (from KEGG)
      Melanoma, conserved biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • NRAGE signals death through JNK, organism-specific biosystem (from REACTOME)
      NRAGE signals death through JNK, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Non-small cell lung cancer, organism-specific biosystem (from KEGG)
      Non-small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
    • Non-small cell lung cancer, conserved biosystem (from KEGG)
      Non-small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Pancreatic cancer, organism-specific biosystem (from KEGG)
      Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pancreatic cancer, conserved biosystem (from KEGG)
      Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Platinum drug resistance, organism-specific biosystem (from KEGG)
      Platinum drug resistance, organism-specific biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. T...
    • Platinum drug resistance, conserved biosystem (from KEGG)
      Platinum drug resistance, conserved biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. T...
    • Programmed Cell Death, organism-specific biosystem (from REACTOME)
      Programmed Cell Death, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Prostate cancer, organism-specific biosystem (from KEGG)
      Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Prostate cancer, conserved biosystem (from KEGG)
      Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Ras signaling pathway, organism-specific biosystem (from KEGG)
      Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Thyroid hormone signaling pathway, organism-specific biosystem (from KEGG)
      Thyroid hormone signaling pathway, organism-specific biosystemThe thyroid hormones (THs) are important regulators of growth, development and metabolism. The action of TH is mainly mediated by T3 (3,5,3'-triiodo-L-thyronine). Thyroid hormones, L-thyroxine (T4) a...
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • VEGF signaling pathway, organism-specific biosystem (from KEGG)
      VEGF signaling pathway, organism-specific biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    • VEGF signaling pathway, conserved biosystem (from KEGG)
      VEGF signaling pathway, conserved biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    • VEGF-receptor Signal Transduction, organism-specific biosystem (from WikiPathways)
      VEGF-receptor Signal Transduction, organism-specific biosystemVEGF Signal transduction in haematopoeitic stem cells, macrophages, monocyten, vascular endothelium and lymphatic endothelium.
    • VEGFR-3 signaling, organism-specific biosystem (from WikiPathways)
      VEGFR-3 signaling, organism-specific biosystemVascular endothelial growth factors are crucial for the vascular development and neovascularization in physiological and pathological processes in both embryo and adult. There are three isoforms of t...
    • Viral carcinogenesis, organism-specific biosystem (from KEGG)
      Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • Viral carcinogenesis, conserved biosystem (from KEGG)
      Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
      cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cAMP signaling pathway, conserved biosystem (from KEGG)
      cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
      cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
    • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
      cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
    • p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
      p75 NTR receptor-mediated signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC72439

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    14-3-3 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cysteine-type endopeptidase activator activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cysteine-type endopeptidase activator activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cysteine-type endopeptidase activator activity involved in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lipid binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    lipid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phospholipid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein kinase B binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein phosphatase 2B binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphatase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    ADP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ADP metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ATP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ATP metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    activation of cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    activation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    activation of cysteine-type endopeptidase activity involved in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular process regulating host cell cycle in response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular process regulating host cell cycle in response to virus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to chromate IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to hypoxia IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to lipid IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to lipid ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to nicotine ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to nicotine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cerebral cortex development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    extrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    extrinsic apoptotic signaling pathway via death domain receptors IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    glucose catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    glucose catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    intrinsic apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intrinsic apoptotic signaling pathway in response to DNA damage IEA
    Inferred from Electronic Annotation
    more info
     
    intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    pore complex assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    pore complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of B cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of apoptotic process by virus IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process by virus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of epithelial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of glucokinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of glucokinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of granulosa cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of insulin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of mitochondrial membrane potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of neuron death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of neuron death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of release of cytochrome c from mitochondria IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of type B pancreatic cell development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of type B pancreatic cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of mitochondrial membrane permeability IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of mitochondrial membrane permeability ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of mitochondrial membrane permeability ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    release of cytochrome c from mitochondria IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to amino acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to benzene IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to calcium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to glucocorticoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to glucose IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hydrogen peroxide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to oleic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to progesterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to testosterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    suppression by virus of host apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    suppression by virus of host apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    type B pancreatic cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    type B pancreatic cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    bcl2-associated agonist of cell death
    Names
    BCL2-associated agonist of cell death, variant 1
    BCL2-associated agonist of cell death, variant 2
    Bcl2-antagonist of cell death
    bcl-2 associated death agonist
    bcl-2-binding component 6
    bcl-xL/Bcl-2-associated death promoter
    bcl2 antagonist of cell death
    bcl2-associated death promoter

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022698.1NP_073189.1  bcl2-associated agonist of cell death

      See identical proteins and their annotated locations for NP_073189.1

      Status: PROVISIONAL

      Source sequence(s)
      AF279910
      UniProtKB/Swiss-Prot
      O35147
      Related
      ENSRNOP00000028712.3, ENSRNOT00000028712.5
      Conserved Domains (1) summary
      pfam10514
      Location:43205
      Bcl-2_BAD; Pro-apoptotic Bcl-2 protein, BAD

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      222198516..222207459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230896.3XP_006230958.1  bcl2-associated agonist of cell death isoform X1

      See identical proteins and their annotated locations for XP_006230958.1

      UniProtKB/Swiss-Prot
      O35147
      Conserved Domains (1) summary
      pfam10514
      Location:43165
      Bcl-2_BAD; Pro-apoptotic Bcl-2 protein, BAD
    2. XM_006230897.3XP_006230959.1  bcl2-associated agonist of cell death isoform X2

      Conserved Domains (1) summary
      pfam10514
      Location:1123
      Bcl-2_BAD; Pro-apoptotic Bcl-2 protein, BAD
    3. XM_006230898.3XP_006230960.1  bcl2-associated agonist of cell death isoform X3

      Conserved Domains (1) summary
      pfam10514
      Location:1163
      Bcl-2_BAD; Pro-apoptotic Bcl-2 protein, BAD

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      201667864..201676765
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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