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    ADCYAP1 adenylate cyclase activating polypeptide 1 [ Bos taurus (cattle) ]

    Gene ID: 615187, updated on 3-Feb-2019

    Summary

    Official Symbol
    ADCYAP1provided by VGNC
    Official Full Name
    adenylate cyclase activating polypeptide 1provided by VGNC
    Primary source
    VGNC:VGNC:25651
    See related
    BGD:BT12089; Ensembl:ENSBTAG00000020650
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    PACAP
    Orthologs

    Genomic context

    See ADCYAP1 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 24 NC_037351.1 (35732908..35739931)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 24 AC_000181.1 (36114443..36121104)

    Chromosome 24 - NC_037351.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112444211 Neighboring gene enolase superfamily member 1 Neighboring gene YES proto-oncogene 1, Src family tyrosine kinase Neighboring gene elongation factor 1-alpha 1 pseudogene Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC140674

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    neuropeptide hormone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptide hormone receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    pituitary adenylate cyclase activating polypeptide activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pituitary adenylate cyclase-activating polypeptide receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cAMP-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    insulin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of growth hormone secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    pituitary adenylate cyclase-activating polypeptide
    Names
    adenylate cyclase activating polypeptide 1 (pituitary)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001046555.1NP_001040020.1  pituitary adenylate cyclase-activating polypeptide precursor

      See identical proteins and their annotated locations for NP_001040020.1

      Status: PROVISIONAL

      Source sequence(s)
      AY924308
      UniProtKB/Swiss-Prot
      Q29W19
      Conserved Domains (1) summary
      pfam00123
      Location:132158
      Hormone_2; Peptide hormone

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037351.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      35732908..35739931
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005224280.4XP_005224337.1  pituitary adenylate cyclase-activating polypeptide isoform X1

      See identical proteins and their annotated locations for XP_005224337.1

      UniProtKB/TrEMBL
      A4FV02
      Related
      ENSBTAP00000027516.4, ENSBTAT00000027516.5
      Conserved Domains (1) summary
      pfam00123
      Location:132158
      Hormone_2; Peptide hormone
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