Format

Send to:

Choose Destination
    • Showing Current items.

    Smad5 SMAD family member 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 59328, updated on 2-Oct-2018

    Summary

    Official Symbol
    Smad5provided by RGD
    Official Full Name
    SMAD family member 5provided by RGD
    Primary source
    RGD:620158
    See related
    Ensembl:ENSRNOG00000022870
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Madh5
    Summary
    may play a role in the healing of bone fractures [RGD, Feb 2006]
    Expression
    Biased expression in Adrenal (RPKM 145.0), Lung (RPKM 139.4) and 9 other tissues See more
    Orthologs

    Genomic context

    See Smad5 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (8307448..8336996, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 17 NC_005116.3 (10484309..10513839, complement)

    Chromosome 17 - NC_005116.4Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily C, member 7 Neighboring gene uncharacterized LOC108348499 Neighboring gene uncharacterized LOC102555284 Neighboring gene uncharacterized LOC102555503 Neighboring gene transforming growth factor, beta induced Neighboring gene leukocyte cell-derived chemotaxin 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    DEAD/H-box RNA helicase binding IEA
    Inferred from Electronic Annotation
    more info
     
    DEAD/H-box RNA helicase binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    BMP signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Mullerian duct regression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    SMAD protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    bone development IEA
    Inferred from Electronic Annotation
    more info
     
    bone development ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    cartilage development IEA
    Inferred from Electronic Annotation
    more info
     
    cartilage development ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to BMP stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic pattern specification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    erythrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    germ cell development IEA
    Inferred from Electronic Annotation
    more info
     
    germ cell development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    ossification IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    osteoblast fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    osteoblast fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of ossification NAS
    Non-traceable Author Statement
    more info
    PubMed 
    transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    ureteric bud development IEA
    Inferred from Electronic Annotation
    more info
     
    ureteric bud development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    mothers against decapentaplegic homolog 5
    Names
    MAD homolog 5
    SMAD 5
    SMAD, mothers against DPP homolog 5
    mothers against DPP homolog 5

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021692.1NP_067724.1  mothers against decapentaplegic homolog 5

      See identical proteins and their annotated locations for NP_067724.1

      Status: PROVISIONAL

      Source sequence(s)
      AB010955
      UniProtKB/Swiss-Prot
      Q9R1V3
      UniProtKB/TrEMBL
      B1WBR0
      Related
      ENSRNOP00000016704.3, ENSRNOT00000016704.4
      Conserved Domains (2) summary
      cd10490
      Location:10133
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cd10497
      Location:265465
      MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005116.4 Reference Rnor_6.0 Primary Assembly

      Range
      8307448..8336996 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600659.1XP_017456148.1  mothers against decapentaplegic homolog 5 isoform X1

      UniProtKB/Swiss-Prot
      Q9R1V3
      UniProtKB/TrEMBL
      B1WBR0
      Conserved Domains (2) summary
      cd10490
      Location:10133
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cd10497
      Location:265465
      MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
    2. XM_006253587.3XP_006253649.1  mothers against decapentaplegic homolog 5 isoform X1

      See identical proteins and their annotated locations for XP_006253649.1

      UniProtKB/Swiss-Prot
      Q9R1V3
      UniProtKB/TrEMBL
      B1WBR0
      Conserved Domains (2) summary
      cd10490
      Location:10133
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cd10497
      Location:265465
      MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
    3. XM_006253586.3XP_006253648.1  mothers against decapentaplegic homolog 5 isoform X1

      See identical proteins and their annotated locations for XP_006253648.1

      UniProtKB/Swiss-Prot
      Q9R1V3
      UniProtKB/TrEMBL
      B1WBR0
      Conserved Domains (2) summary
      cd10490
      Location:10133
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cd10497
      Location:265465
      MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
    4. XM_008771448.2XP_008769670.1  mothers against decapentaplegic homolog 5 isoform X1

      See identical proteins and their annotated locations for XP_008769670.1

      UniProtKB/Swiss-Prot
      Q9R1V3
      UniProtKB/TrEMBL
      B1WBR0
      Conserved Domains (2) summary
      cd10490
      Location:10133
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cd10497
      Location:265465
      MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
    5. XM_017600658.1XP_017456147.1  mothers against decapentaplegic homolog 5 isoform X1

      UniProtKB/Swiss-Prot
      Q9R1V3
      UniProtKB/TrEMBL
      B1WBR0
      Conserved Domains (2) summary
      cd10490
      Location:10133
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cd10497
      Location:265465
      MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
    6. XM_006253588.3XP_006253650.1  mothers against decapentaplegic homolog 5 isoform X1

      See identical proteins and their annotated locations for XP_006253650.1

      UniProtKB/Swiss-Prot
      Q9R1V3
      UniProtKB/TrEMBL
      B1WBR0
      Conserved Domains (2) summary
      cd10490
      Location:10133
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cd10497
      Location:265465
      MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
    7. XM_017600657.1XP_017456146.1  mothers against decapentaplegic homolog 5 isoform X1

      UniProtKB/Swiss-Prot
      Q9R1V3
      UniProtKB/TrEMBL
      B1WBR0
      Conserved Domains (2) summary
      cd10490
      Location:10133
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cd10497
      Location:265465
      MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
    8. XM_008771447.2XP_008769669.1  mothers against decapentaplegic homolog 5 isoform X1

      See identical proteins and their annotated locations for XP_008769669.1

      UniProtKB/Swiss-Prot
      Q9R1V3
      UniProtKB/TrEMBL
      B1WBR0
      Conserved Domains (2) summary
      cd10490
      Location:10133
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cd10497
      Location:265465
      MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

    Alternate Rn_Celera

    Genomic

    1. AC_000085.1 Alternate Rn_Celera

      Range
      7961603..7971797 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center