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    Apln apelin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58812, updated on 18-Apr-2019

    Summary

    Official Symbol
    Aplnprovided by RGD
    Official Full Name
    apelinprovided by RGD
    Primary source
    RGD:620672
    See related
    Ensembl:ENSRNOG00000003984
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Apel
    Expression
    Biased expression in Lung (RPKM 268.4), Heart (RPKM 80.4) and 5 other tissues See more
    Orthologs

    Genomic context

    See Apln in Genome Data Viewer
    Location:
    Xq36
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (134856719..134866210, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) X NC_005120.3 (134929116..134938607, complement)

    Chromosome X - NC_005120.4Genomic Context describing neighboring genes Neighboring gene similar to karyopherin (importin) alpha 2 Neighboring gene OCRL, inositol polyphosphate-5-phosphatase Neighboring gene X-prolyl aminopeptidase 2 Neighboring gene SAM and SH3 domain containing 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    apelin receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apelin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    hormone activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    hormone activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    apelin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apelin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    apelin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    coronary vasculature development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    coronary vasculature development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    drinking behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    gastrulation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of blood pressure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of vascular smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of vascular smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of vasoconstriction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of G protein-coupled receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of G protein-coupled receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of blood vessel diameter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of corticotropin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of corticotropin-releasing hormone secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of heat generation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of pri-miRNA transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of pri-miRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of vascular endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of vascular endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of body fluid levels IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of respiratory gaseous exchange IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of the force of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    apelin
    Names
    APJ endogenous ligand
    apelin, AGTRL1 ligand

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031612.3NP_113800.1  apelin preproprotein

      See identical proteins and their annotated locations for NP_113800.1

      Status: VALIDATED

      Source sequence(s)
      AC127934, BC080843
      UniProtKB/Swiss-Prot
      Q9R0R3
      Related
      ENSRNOP00000005331.3, ENSRNOT00000005331.5
      Conserved Domains (1) summary
      pfam15360
      Location:2377
      Apelin; APJ endogenous ligand

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005120.4 Reference Rnor_6.0 Primary Assembly

      Range
      134856719..134866210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000089.1 Alternate Rn_Celera

      Range
      126154452..126163943 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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