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    AGTRAP angiotensin II receptor associated protein [ Homo sapiens (human) ]

    Gene ID: 57085, updated on 15-Apr-2019

    Summary

    Official Symbol
    AGTRAPprovided by HGNC
    Official Full Name
    angiotensin II receptor associated proteinprovided by HGNC
    Primary source
    HGNC:HGNC:13539
    See related
    Ensembl:ENSG00000177674 MIM:608729
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATRAP
    Summary
    This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 38.0), prostate (RPKM 28.1) and 25 other tissues See more
    Orthologs

    Genomic context

    See AGTRAP in Genome Data Viewer
    Location:
    1p36.22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (11736085..11750771)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (11796142..11810828)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene F-box protein 6 Neighboring gene mitotic arrest deficient 2 like 2 Neighboring gene dorsal inhibitory axon guidance protein Neighboring gene atrophin-1-like Neighboring gene chromosome 1 open reading frame 167 Neighboring gene uncharacterized LOC102724659

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Diseases of signal transduction, organism-specific biosystem (from REACTOME)
      Diseases of signal transduction, organism-specific biosystemSignaling processes are central to human physiology (e.g., Pires-da Silva & Sommer 2003), and their disruption by either germ-line and somatic mutation can lead to serious disease. Here, the molecula...
    • Oncogenic MAPK signaling, organism-specific biosystem (from REACTOME)
      Oncogenic MAPK signaling, organism-specific biosystemThe importance of the RAS/RAF/MAPK cascade in regulating cellular proliferation, differentiation and survival is highlighted by the fact that components of the pathway are mutated with high frequency...
    • Signaling by BRAF and RAF fusions, organism-specific biosystem (from REACTOME)
      Signaling by BRAF and RAF fusions, organism-specific biosystemIn addition to the more prevalent point mutations, BRAF and RAF1 are also subject to activation as a result of translocation events that yield truncated or fusion products (Jones et al, 2008; Cin et ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC29646

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    angiotensin type II receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    angiotensin-activated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    type-1 angiotensin II receptor-associated protein
    Names
    AT1 receptor-associated protein
    ATI receptor-associated protein
    angiotensin II, type I receptor-associated protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040194.1NP_001035284.1  type-1 angiotensin II receptor-associated protein isoform b

      See identical proteins and their annotated locations for NP_001035284.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      AI741916, BC017328, BI117521, BQ672962, CA866314
      Consensus CDS
      CCDS30585.1
      UniProtKB/Swiss-Prot
      Q6RW13
      Related
      ENSP00000365816.4, ENST00000376629.8
      Conserved Domains (1) summary
      pfam06396
      Location:9145
      AGTRAP; Angiotensin II, type I receptor-associated protein (AGTRAP)
    2. NM_001040195.1NP_001035285.1  type-1 angiotensin II receptor-associated protein isoform c

      See identical proteins and their annotated locations for NP_001035285.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon and uses an alternate splice site for a second exon in the 3' coding region, compared to variant 1, resulting in a frameshift. The resulting protein (isoform c) has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AI741916, BC017328, BI117521, BQ672962, CA866314
      Consensus CDS
      CCDS30586.1
      UniProtKB/Swiss-Prot
      Q6RW13
      Related
      ENSP00000365824.3, ENST00000376637.7
    3. NM_001040196.1NP_001035286.1  type-1 angiotensin II receptor-associated protein isoform d

      See identical proteins and their annotated locations for NP_001035286.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) includes an alternate exon and uses an alternate splice site for a second exon in the 3' coding region, compared to variant 1, resulting in a frameshift. The resulting protein (isoform d) has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AI741916, BC017328, BE782705, BI117521, BQ672962, CA866314
      Consensus CDS
      CCDS44056.1
      UniProtKB/Swiss-Prot
      Q6RW13
      Related
      ENSP00000408505.2, ENST00000452018.6
      Conserved Domains (1) summary
      cl05741
      Location:120
      AGTRAP; Angiotensin II, type I receptor-associated protein (AGTRAP)
    4. NM_001040197.1NP_001035287.1  type-1 angiotensin II receptor-associated protein isoform e

      See identical proteins and their annotated locations for NP_001035287.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) includes an alternate exon in the coding region, compared to variant 1, resulting in a frameshift. The resulting protein (isoform e) has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AI741916, BC017328, BE782705, BI117521, BQ672962, CA866314, CD674964
      Consensus CDS
      CCDS41248.1
      UniProtKB/Swiss-Prot
      Q6RW13
      Related
      ENSP00000383688.2, ENST00000400895.6
      Conserved Domains (1) summary
      cl05741
      Location:120
      AGTRAP; Angiotensin II, type I receptor-associated protein (AGTRAP)
    5. NM_020350.5NP_065083.3  type-1 angiotensin II receptor-associated protein isoform a

      See identical proteins and their annotated locations for NP_065083.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant represents the most common transcript and encodes isoform a.
      Source sequence(s)
      AF312374, AI741916, BC017328, BI117521, BQ672962
      Consensus CDS
      CCDS136.1
      UniProtKB/Swiss-Prot
      Q6RW13
      Related
      ENSP00000319713.5, ENST00000314340.10
      Conserved Domains (1) summary
      pfam06396
      Location:9152
      AGTRAP; Angiotensin II, type I receptor-associated protein (AGTRAP)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      11736085..11750771
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541802.2XP_011540104.1  type-1 angiotensin II receptor-associated protein isoform X2

      Related
      ENSP00000365814.1, ENST00000376627.6
    2. XM_011541800.3XP_011540102.1  type-1 angiotensin II receptor-associated protein isoform X1

      Conserved Domains (1) summary
      pfam06396
      Location:22164
      AGTRAP; Angiotensin II, type I receptor-associated protein (AGTRAP)
    3. XM_011541799.3XP_011540101.2  type-1 angiotensin II receptor-associated protein isoform X3

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