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    Adam22 ADAM metallopeptidase domain 22 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 57033, updated on 19-Apr-2019

    Summary

    Symbol
    Adam22provided by RGD
    Full Name
    ADAM metallopeptidase domain 22provided by RGD
    Primary source
    RGD:1585016
    See related
    Ensembl:ENSRNOG00000042478
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MDC2
    Summary
    metalloprotease-disintegrin containing a catalytic zinc ion with moderate sequence similarity to human metalloproteinase-disintegrin domain 22 (MDC2 delta), isoform 1 preproprotein [RGD, Feb 2006]
    Expression
    Biased expression in Brain (RPKM 418.8), Kidney (RPKM 61.5) and 1 other tissue See more

    Genomic context

    See Adam22 in Genome Data Viewer
    Location:
    4q12
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (22864485..23002969)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (22632816..22827454) , (22873544..22935588)

    Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene protein DBF4 homolog A-like Neighboring gene disintegrin and metalloproteinase domain-containing protein 22-like Neighboring gene uncharacterized LOC102556240 Neighboring gene DBF4 zinc finger Neighboring gene uncharacterized LOC102547122 Neighboring gene sorcin

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Schwann cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    adult locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    adult locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    gliogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    myelination in peripheral nervous system IEA
    Inferred from Electronic Annotation
    more info
     
    myelination in peripheral nervous system ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neurotransmitter receptor localization to postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    axon IEA
    Inferred from Electronic Annotation
    more info
     
    axon ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    integral component of postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 22
    Names
    a disintegrin and metalloprotease domain (ADAM) 22
    a disintegrin and metalloprotease domain 22

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

      Range
      22864485..23002969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017592940.1XP_017448429.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X1

    2. XM_017592941.1XP_017448430.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X2

    3. XM_017592944.1XP_017448433.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X5

    4. XM_017592943.1XP_017448432.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X4

    5. XM_017592947.1XP_017448436.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X8

    6. XM_017592946.1XP_017448435.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X7

    7. XM_017592942.1XP_017448431.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X3

    8. XM_017592945.1XP_017448434.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X6

    9. XM_017592950.1XP_017448439.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X11

    10. XM_017592948.1XP_017448437.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X9

    11. XM_017592949.1XP_017448438.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X10

      Related
      ENSRNOP00000064723.2, ENSRNOT00000073501.3
    12. XM_017592951.1XP_017448440.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X12

      Related
      ENSRNOP00000059289.3, ENSRNOT00000068410.4

    RNA

    1. XR_001837516.1 RNA Sequence

    Alternate Rn_Celera

    Genomic

    1. AC_000072.1 Alternate Rn_Celera

      Range
      21356458..21453378
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017602738.1XP_017458227.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X1

    2. XM_017602739.1XP_017458228.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X2

    3. XM_017602741.1XP_017458230.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X4

    4. XM_017602742.1XP_017458231.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X5

    5. XM_017602745.1XP_017458234.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X8

    6. XM_017602744.1XP_017458233.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X7

    7. XM_017602740.1XP_017458229.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X3

    8. XM_017602743.1XP_017458232.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X6

    9. XM_017602748.1XP_017458237.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X11

    10. XM_017602746.1XP_017458235.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X9

    11. XM_017602747.1XP_017458236.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X10

    12. XM_017602749.1XP_017458238.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X12

    RNA

    1. XR_001843290.1 RNA Sequence

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